Evidence map›Paper›PMID 21527105›Full record

ArticleJournal of diabetes science and technology2011

Assessment of blood glucose control in the pediatric intensive care unit: extension of the glycemic penalty index toward children and infants.

Tom Van Herpe, Marijke Gielen, Koen Vanhonsebrouck, Pieter J Wouters, Greet Van den Berghe, Bart De Moor, Dieter Mesotten

Abstract read
In one paragraph

Article in Journal of diabetes science and technology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tom Van HerpeDepartment of Intensive Care Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium. tom.vanherpe@esat.kuleuven.be
Marijke Gielen
Koen Vanhonsebrouck
Pieter J Wouters
Greet Van den Berghe
Bart De Moor
Dieter Mesotten

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe glycemic penalty index (GPI) is a measure to assess blood glucose (BG) control in critically ill adult patients but needs to be adapted for children and infants.

methodThe squared differences between a clinical expertise penalty function and the corresponding polynomial function are minimized for optimization purposes. The average of all penalties (individually assigned to all BG readings) represents the patient-specific GPI.

resultsPenalization in the hypoglycemic range is more severe than in the hyperglycemic range as the developing brains of infants and children may be more vulnerable to hypoglycemia. Similarly, hypoglycemia is also more heavily penalized in infants than in children.

conclusionsExtending the adult GPI toward the age-specific GPI is an important methodological step. Long-term clinical studies are needed to determine the clinically acceptable GPI cut-off level.

Indexed as

Blood GlucoseChildChild, PreschoolCritical CareCritical IllnessDose-Response Relationship, DrugHumansHypoglycemiaInfantInfant, NewbornIntensive Care Units, PediatricModels, StatisticalMonitoring, PhysiologicReference ValuesBlood Glucose

Identifiers

PMID21527105
PMCPMC3125928

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.