ArticlePloS one2011
Lhx1 is required for specification of the renal progenitor cell field.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- GRNFormer: accurate gene regulatory network inference using graph transformer.Bioinformatics (Oxford, England) · 2026Article
- Isocitrate Dehydrogenases Idh1 and Idh2 Regulate Pronephric Morphogenesis inDevelopment & reproduction · 2026Article
- Postembryonic Maintenance of Nephron Progenitor Cells with Low Translational Activity in the Chondrichthyan Scyliorhinus canicula.Journal of the American Society of Nephrology : JASN · 2025Article
- Comparative analysis ofbioRxiv : the preprint server for biology · 2025Article
- An antagonistic role of clock genes and lima1 in kidney regeneration.Communications biology · 2025Article
- Kidney-specific methylation patterns correlate with kidney function and are lost upon kidney disease progression.Clinical epigenetics · 2024Article
- HNF1β, LHX1, and GGNBP2 deletion contributed to kidney and reproductive dysfunction in 17q12 deletion syndrome: evidence from a case report.Frontiers in genetics · 2024Article
- Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation.Scientific reports · 2023Article
- Review
- A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery.Cell stem cell · 2022Article
- Renal Autologous Cell Therapy to Stabilize Function in Diabetes-Related Chronic Kidney Disease: Corroboration of Mechanistic Action With Cell Marker Analysis.Kidney international reports · 2022Article
- The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos.Communications biology · 2021Article
- Transgenic fluorescent zebrafish lines that have revolutionized biomedical research.Laboratory animal research · 2021Review
- Review
- osr1 couples intermediate mesoderm cell fate with temporal dynamics of vessel progenitor cell differentiation.Development (Cambridge, England) · 2021Article
- Furry is required for cell movements during gastrulation and functionally interacts with NDR1.Scientific reports · 2021Article
- Article
- The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma.Oncogene · 2019Article
- The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development.Scientific reports · 2018Article
- Tissue-Specific Gene Inactivation inGenetics · 2018Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
In the vertebrate embryo, the kidney is derived from the intermediate mesoderm. The LIM-class homeobox transcription factor lhx1 is expressed early in the intermediate mesoderm and is one of the first genes to be expressed in the nephric mesenchyme. In this study, we investigated the role of Lhx1 in specification of the kidney field by either overexpressing or depleting lhx1 in Xenopus embryos or depleting lhx1 in an explant culture system. By overexpressing a constitutively-active form of Lhx1, we established its capacity to expand the kidney field during the specification stage of kidney organogenesis. In addition, the ability of Lhx1 to expand the kidney field diminishes as kidney organogenesis transitions to the morphogenesis stage. In a complimentary set of experiments, we determined that embryos depleted of lhx1, show an almost complete loss of the kidney field. Using an explant culture system to induce kidney tissue, we confirmed that expression of genes from both proximal and distal kidney structures is affected by the absence of lhx1. Taken together our results demonstrate an essential role for Lhx1 in driving specification of the entire kidney field from the intermediate mesoderm.
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