ArticlePloS one2011
Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating selected features of TGFβ inhibition.BMC cancer · 2022Article
- 3D modeling in cancer studies.Human cell · 2022Review
- Role of extracellular matrix architecture and signaling in melanoma therapeutic resistance.Frontiers in oncology · 2022Review
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- Bad company: Microenvironmentally mediated resistance to targeted therapy in melanoma.Pigment cell & melanoma research · 2019Review
- CeModule: an integrative framework for discovering regulatory patterns from genomic data in cancer.BMC bioinformatics · 2019Article
- High Expression B3GAT3 Is Related with Poor Prognosis of Liver Cancer.Open medicine (Warsaw, Poland) · 2019Article
- Regulation of HGF and c-MET Interaction in Normal Ovary and Ovarian Cancer.Reproductive sciences (Thousand Oaks, Calif.) · 2017Review
- Exosomes as mediators of platinum resistance in ovarian cancer.Oncotarget · 2017Article
- Article
- A computational approach to identifying gene-microRNA modules in cancer.PLoS computational biology · 2015Article
- Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.The Journal of clinical investigation · 2014Article
- Miniaturized pre-clinical cancer models as research and diagnostic tools.Advanced drug delivery reviews · 2014Review
- The wound healing, chronic fibrosis, and cancer progression triad.Physiological genomics · 2014Review
- Metastasis of ovarian cancer is mediated by kallikrein related peptidases.Clinical & experimental metastasis · 2014Review
- Culture models to define key mediators of cancer matrix remodeling.Frontiers in oncology · 2014Review
- Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment.Oncogenesis · 2013Article
- Pre-Treatment of platinum resistant ovarian cancer cells with an MMP-9/MMP-2 inhibitor prior to cisplatin enhances cytotoxicity as determined by high content screening.International journal of molecular sciences · 2013Article
- Transcriptional regulation of hTREX84 in human cancer cells.PloS one · 2012Article
- Overexpression of CD157 contributes to epithelial ovarian cancer progression by promoting mesenchymal differentiation.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Epithelial ovarian cancer is an aggressive and deadly disease and understanding its invasion mechanisms is critical for its treatment. We sought to study the penetration/invasion of ovarian tumor cells into extracellular matrices (ECMs) using a fibroblast-derived three-dimensional (3D) culture model and time-lapse and confocal imaging. Twelve ovarian tumor cells were evaluated and classified into distinct groups based on their ECM remodeling phenotypes; those that degraded the ECM (represented by OVCAR5 cells) and those that did not (represented by OVCAR10 cells). Cells exhibiting a distinct ECM modifying behavior were also segregated by epithelial- or mesenchymal-like phenotypes and uPA or MMP-2/MMP-9 expression. The cells, which presented epithelial-like phenotypes, penetrated the ECM using proteases and maintained intact cell-cell interactions, while cells exhibiting mesenchymal phenotypes modified the matrices via Rho-associated serine/threonine kinase (ROCK) in the absence of apparent cell-cell interactions. Overall, this study demonstrates that different mechanisms of modifying matrices by ovarian tumor cells may reflect heterogeneity among tumors and emphasize the need to systematically assess these mechanisms to better design effective therapies.
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