ArticlePloS one2011
Sex differences in sand lizard telomere inheritance: paternal epigenetic effects increases telomere heritability and offspring survival.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Telomere Length Is Determined by Intrinsic Factors and Is Shortened During Drought Years inEcology and evolution · 2026Article
- Sex and early-life conditions shape telomere dynamics in an ectotherm.The Journal of experimental biology · 2024Article
- Context-dependent thermolability of sex determination in a lacertid lizard with heteromorphic sex chromosomes.Biology open · 2023Article
- Inbreeding effects on telomeres in hatchling sand lizards (Lacerta agilis): An optimal family affair?Molecular ecology · 2022Article
- Lizards from warm and declining populations are born with extremely short telomeres.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Evidence of Paternal Effects on Telomere Length Increases in Early Life.Frontiers in genetics · 2022Article
- Parental age at conception on mouse lemur's offspring longevity: Sex-specific maternal effects.PloS one · 2022Article
- Article
- Longitudinal evidence that older parents produce offspring with longer telomeres in a wild social bird.Biology letters · 2021Article
- Individual telomere dynamics and their links to life history in a viviparous lizard.Proceedings. Biological sciences · 2021Article
- Article
- Contrasting seasonal patterns of telomere dynamics in response to environmental conditions in the ectothermic sand lizard, Lacerta agilis.Scientific reports · 2020Article
- The untapped potential of reptile biodiversity for understanding how and why animals age.Functional ecology · 2020Article
- The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness.Proceedings. Biological sciences · 2019Article
- Intergenerational effects on offspring telomere length: interactions among maternal age, stress exposure and offspring sex.Proceedings. Biological sciences · 2019Article
- Telomere attrition predicts reduced survival in a wild social bird, but short telomeres do not.Molecular ecology · 2019Article
- The environmental and genetic determinants of chick telomere length in Tree Swallows (Ecology and evolution · 2019Article
- Paternal age at conception effects on offspring telomere length across species-What explains the variability?PLoS genetics · 2019Article
- Transgenerational telomere erosion in the monogametic sex: human telomeres progressively erode in the female germline and do not lengthen in aged testes.Molecular cytogenetics · 2019Article
- Reduced telomere length in offspring of old fathers in a long-lived seabird.Biology letters · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, the only estimate of the heritability of telomere length in wild populations comes from humans. Thus, there is a need for analysis of natural populations with respect to how telomeres evolve. METHODOLOGY/PRINCIPAL
findingsHere, we show that telomere length is heritable in free-ranging sand lizards, Lacerta agilis. More importantly, heritability estimates analysed within, and contrasted between, the sexes are markedly different; son-sire heritability is much higher relative to daughter-dam heritability. We assess the effect of paternal age on Telomere Length (TL) and show that in this species, paternal age at conception is the best predictor of TL in sons. Neither paternal age per se at blood sampling for telomere screening, nor corresponding age in sons impact TL in sons. Processes maintaining telomere length are also associated with negative fitness effects, most notably by increasing the risk of cancer and show variation across different categories of individuals (e.g. males vs. females). We therefore tested whether TL influences offspring survival in their first year of life. Indeed such effects were present and independent of sex-biased offspring mortality and offspring malformations. CONCLUSIONS/SIGNIFICANCE: TL show differences in sex-specific heritability with implications for differences between the sexes with respect to ongoing telomere selection. Paternal age influences the length of telomeres in sons and longer telomeres enhance offspring survival.
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