ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Resting glutamate levels and rapid glutamate transients in the prefrontal cortex of the Flinders Sensitive Line rat: a genetic rodent model of depression.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression.Pharmaceutics · 2023Review
- Amyloid-βScientific reports · 2022Article
- Deuterated Glutamate-Mediated Neuronal Activity on Micro-Electrode Arrays.Micromachines · 2020Article
- Chronic Methylphenidate Alters Tonic and Phasic Glutamate Signaling in the Frontal Cortex of a Freely-Moving Rat Model of ADHD.Neurochemical research · 2019Article
- Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AβPP/PS1 mice.Journal of neurochemistry · 2019Article
- Genetic Modulation at the Neural Microelectrode Interface: Methods and Applications.Micromachines · 2018Article
- Amperometric Self-Referencing Ceramic Based Microelectrode Arrays for D-Serine Detection.Biosensors · 2018Article
- Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn-1 gene.Brain and behavior · 2017Article
- Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Therapeutic Effect of Astroglia-like Mesenchymal Stem Cells Expressing Glutamate Transporter in a Genetic Rat Model of Depression.Theranostics · 2017Article
- Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice.Metabolic brain disease · 2016Article
- Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation.Journal of neuroscience methods · 2015Article
- Article
- An update of the classical and novel methods used for measuring fast neurotransmitters during normal and brain altered function.Current neuropharmacology · 2014Article
- Electrochemical techniques for subsecond neurotransmitter detection in live rodents.Comparative medicine · 2014Review
- Synaptic abnormalities in the infralimbic cortex of a model of congenital depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Ketamine regulates the presynaptic release machinery in the hippocampus.Journal of psychiatric research · 2013Article
- Glutaraldehyde cross-linked glutamate oxidase coated microelectrode arrays: selectivity and resting levels of glutamate in the CNS.ACS chemical neuroscience · 2013Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Despite the numerous drugs targeting biogenic amines for major depressive disorder (depression), the search for novel therapeutics continues because of their poor response rates (~30%) and slow onset of action (2-4 weeks). To better understand role of glutamate in depression, we used an enzyme-based microelectrode array (MEA) that was selective for glutamate measures with fast temporal (2 Hz) and high spatial (15 × 333 μm) resolution. These MEAs were chronically implanted into the prefrontal cortex of 3- to 6-month-old and 12- to 15-month-old Flinders Sensitive Line (FSL) and control Flinders Resistant Line (FRL) rats, a validated genetic rodent model of depression. Although no changes in glutamate dynamics were observed between 3 and 6 months FRL and FSL rats, a significant increase in resting glutamate levels was observed in the 12- to 15-month-old FSL rats compared with the 3- to 6-month-old FSL and age-matched FRL rats on days 3-5 post-implantation. Our MEA also recorded, for the first time, a unique phenomenon in all the four rat groups of fluctuations in resting glutamate, which we have termed glutamate transients. Although these events lasted only for seconds, they did occur throughout the testing paradigm. The average concentration of these glutamate-burst events was significantly increased in the 12- to 15-month-old FSL rats compared with 3- to 6-month-old FSL and age-matched FRL rats. These studies lay the foundation for future studies of both tonic and phasic glutamate signaling in rat models of depression to better understand the potential role of glutamate signaling in depression.
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