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Morphogen gradient formation and action: insights from studying Bicoid protein degradation.
Article in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis.Molecular systems biology · 2018Article
- Article
- Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo.Development (Cambridge, England) · 2015Article
- Probing the impact of temperature on molecular events in a developmental system.Scientific reports · 2015Article
- Bicoid signal extraction with a selection of parametric and nonparametric signal processing techniques.Genomics, proteomics & bioinformatics · 2015Article
- Fundamental origins and limits for scaling a maternal morphogen gradient.Nature communications · 2015Article
- Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos.Development (Cambridge, England) · 2014Article
- Reverse-engineering post-transcriptional regulation of gap genes in Drosophila melanogaster.PLoS computational biology · 2013Article
- Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila.Nature communications · 2013Article
- Uncovering a dynamic feature of the transcriptional regulatory network for anterior-posterior patterning in the Drosophila embryo.PloS one · 2013Article
- Evaluating the Drosophila Bicoid morphogen gradient system through dissecting the noise in transcriptional bursts.Bioinformatics (Oxford, England) · 2012Article
- Transcriptional activators and activation mechanisms.Protein & cell · 2011Review
- Scaling of the Bicoid morphogen gradient by a volume-dependent production rate.Development (Cambridge, England) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a recent publication, we identified a novel F-box protein, encoded by fates-shifted (fsd), that plays a role in targeting Bcd for ubiquitination and degradation. Our analysis of mutant Drosophila embryos suggests that Bcd protein degradation is important for proper gradient formation and developmental fate specification. Here we describe further experiments that lead to an estimate of Bcd half-life, < 15 min, in embryos during the time of gradient formation. We use our findings to evaluate different models of Bcd gradient formation. With this new estimate, we simulate the Bcd gradient formation process in our own biologically realistic 2-D model. Finally, we discuss the role of Bcd-encoded positional information in controlling the positioning and precision of developmental decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.