Trial reportScience translational medicine2011
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss.
Trial report in Science translational medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 217 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evidence-Based Approach to Dietary Management of Prader-Willi Syndrome (PWS)
Metabolic Impact of Dietary Protein Supplementation in Surgical Weight Loss II (MIPS II)
Who cites it
217 citing papers in PubMed, 4 syntheses or guidelines pooled it, 386 citations in OpenAlex.
- Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.PloS one · 2021Pooled it
- Contribution of Malabsorption to Weight Loss After Roux-en-Y Gastric Bypass: a Systematic Review.Obesity surgery · 2017Pooled it
- Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Pooled it
- Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes.International journal of epidemiology · 2016Pooled it
- Metabolomic Fingerprints of Medical Therapy Versus Bariatric Surgery in Patients With Obesity and Type 2 Diabetes: The STAMPEDE Trial.Diabetes care · 2024Trial
- The Metabolomic Effects of Tripeptide Gut Hormone Infusion Compared to Roux-en-Y Gastric Bypass and Caloric Restriction.The Journal of clinical endocrinology and metabolism · 2022Trial
- Metabolites and diabetes remission after weight loss.Nutrition & diabetes · 2021Trial
- Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes.The New England journal of medicine · 2020Trial
- Effectiveness of vitamin D therapy in improving metabolomic biomarkers in obesity phenotypes: Two randomized clinical trials.International journal of obesity (2005) · 2018Trial
- Adipose tissue mitochondrial capacity associates with long-term weight loss success.International journal of obesity (2005) · 2018Trial
- Weight loss is associated with plasma free amino acid alterations in subjects with metabolic syndrome.Nutrition & diabetes · 2016Trial
- Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials.The American journal of clinical nutrition · 2016Trial
- Effect of insulin sensitizer therapy on amino acids and their metabolites.Metabolism: clinical and experimental · 2015Trial
- Trial
- Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction.Annals of surgery · 2014Trial
- Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin.PloS one · 2014Trial
- The metabolic signature associated with the Western dietary pattern: a cross-sectional study.Nutrition journal · 2013Trial
- Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.Diabetes · 2013Trial
- Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness.Metabolism: clinical and experimental · 2013Trial
- Sleeve Gastrectomy Reverses Hepatic and Circulating Transcriptomic Dysregulation by Restoring Lipid and Energy Metabolism in Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Rats.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
157 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
Glycemic control is improved more after gastric bypass surgery (GBP) than after equivalent diet-induced weight loss in patients with morbid obesity and type 2 diabetes mellitus. We applied metabolomic profiling to understand the mechanisms of this better metabolic response after GBP. Circulating amino acids (AAs) and acylcarnitines (ACs) were measured in plasma from fasted subjects by targeted tandem mass spectrometry before and after a matched 10-kilogram weight loss induced by GBP or diet. Total AAs and branched-chain AAs (BCAAs) decreased after GBP, but not after dietary intervention. Metabolites derived from BCAA oxidation also decreased only after GBP. Principal components (PC) analysis identified two major PCs, one composed almost exclusively of ACs (PC1) and another with BCAAs and their metabolites as major contributors (PC2). PC1 and PC2 were inversely correlated with pro-insulin concentrations, the C-peptide response to oral glucose, and the insulin sensitivity index after weight loss, whereas PC2 was uniquely correlated with levels of insulin resistance (HOMA-IR). These data suggest that the enhanced decrease in circulating AAs after GBP occurs by mechanisms other than weight loss and may contribute to the better improvement in glucose homeostasis observed with the surgical intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.