ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Somatically diversified and proliferating transitional B cells: implications for peripheral B cell homeostasis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Differences in mouse and human nonmemory B cell pools.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Importance of B cells (Review).International journal of molecular medicine · 2026Review
- Chemokine-mediated B cell trafficking during early rabbit GALT development.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Development of CD27+ marginal zone B cells requires GALT.European journal of immunology · 2013Article
- Immunotoxicological impact of engineered nanomaterial exposure: mechanisms of immune cell modulation.Toxicology mechanisms and methods · 2013Review
- Mechanism for pre-B cell loss in VH-mutant rabbits.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The peripheral B cell compartment in mice and humans is maintained by continuous production of transitional B cells in the bone marrow. In other species, however, including rabbits, B lymphopoiesis in the bone marrow abates early in life, and it is unclear how the peripheral B cell compartment is maintained. We identified transitional B cells in rabbits and classified them into T1 (CD24(high)CD21(low)) and T2 (CD24(high)CD21(+)) B cell subsets. By neutralizing B cell-activating factor in vivo, we found an arrest in peripheral B cell development at the T1 B cell stage. Surprisingly, T1 B cells were present in GALT, blood, and spleen of adult rabbits, long after B lymphopoiesis was arrested. T1 B cells were distinct from their counterparts in other species because they are proliferating and the Ig genes are somatically diversified. We designate these newly described cells as T1d B cells and propose a model in which they develop in GALT, self renew, continuously differentiate into mature B cells, and thereby maintain peripheral B cell homeostasis in adults in the absence of B lymphopoiesis.
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Registered trials
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