ArticleThe Journal of experimental biology2011
Histaminergic signaling in the central nervous system of Daphnia and a role for it in the control of phototactic behavior.
Article in The Journal of experimental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
- A web-based histology atlas for the freshwater sentinel species Daphnia magna.The Science of the total environment · 2025Article
- Investigation of potential behavioral and physiological effects of caffeine on D. magna.Environmental science and pollution research international · 2022Article
- Pharmacological modulation of fish-induced depth selection in D. magna: the role of cholinergic and GABAergic signalling.Scientific reports · 2021Article
- Assessment and comparison of putative amine receptor complement/diversity in the brain and eyestalk ganglia of the lobster, Homarus americanus.Invertebrate neuroscience : IN · 2020Article
- Histaminergic interneurons in the ventral nerve cord: assessment of their value for Euarthropod phylogeny.Zoological letters · 2019Article
- Molecular characterization of putative neuropeptide, amine, diffusible gas and small molecule transmitter biosynthetic enzymes in the eyestalk ganglia of the American lobster, Homarus americanus.Invertebrate neuroscience : IN · 2018Article
- Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants.Environmental science & technology · 2015Article
- Identification and developmental expression of the enzymes responsible for dopamine, histamine, octopamine and serotonin biosynthesis in the copepod crustacean Calanus finmarchicus.General and comparative endocrinology · 2014Article
- Prediction of the protein components of a putative Calanus finmarchicus (Crustacea, Copepoda) circadian signaling system using a de novo assembled transcriptome.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2013Article
- Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia.The Journal of experimental biology · 2013Article
- Sublethal silver and NaCl toxicity in Daphnia magna: a comparative study of standardized chronic endpoints and progeny phototaxis.Ecotoxicology (London, England) · 2013Article
- Glutamate-gated chloride channels.The Journal of biological chemistry · 2012Review
- Histamine is a modulator of metamorphic competence in Strongylocentrotus purpuratus (Echinodermata: Echinoidea).BMC developmental biology · 2012Article
- Article
- Genomic identification of a putative circadian system in the cladoceran crustacean Daphnia pulex.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Daphnia magna and Daphnia pulex are well-established model organisms in the fields of ecotoxicology and toxicogenomics. Among the many assays used for determining the effects of environmental and anthropogenic stressors on these animals is monitoring for changes in their phototactic behavior. In most arthropods, histamine has been shown to play a key role in the visual system. Currently, nothing is known about histaminergic signaling in either D. magna or D. pulex. Here, a combination of immunohistochemistry and genome mining was used to identify and characterize the histaminergic systems in these daphnids. In addition, a behavioral assay was used to assess the role of histamine in their phototactic response to ultraviolet (UV) light exposure. An extensive network of histaminergic somata, axons and neuropil was identified via immunohistochemistry within the central nervous system of both daphnids, including labeling of putative photoreceptors in the compound eye and projections from these cells to the brain. Mining of the D. pulex genome using known Drosophila melanogaster proteins identified a putative ortholog of histidine decarboxylase (the rate-limiting biosynthetic enzyme for histamine), as well as two putative histamine-gated chloride channels (hclA and hclB orthologs). Exposure of D. magna to cimetidine, an H2 receptor antagonist known to block both hclA and hclB in D. melanogaster, inhibited their negative phototactic response to UV exposure in a reversible, time-dependent manner. Taken collectively, our results show that an extensive histaminergic system is present in Daphnia species, including the visual system, and that this amine is involved in the control of phototaxis in these animals.
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Registered trials
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