ArticleMathematical medicine and biology : a journal of the IMA2012
Spontaneous oscillations in a model for active control of microvessel diameters.
Article in Mathematical medicine and biology : a journal of the IMA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Vasomotion in Retinal Arterioles Is Modified by Exercise and Flicker Stimulation.Investigative ophthalmology & visual science · 2022Article
- Functional implications of microvascular heterogeneity for oxygen uptake and utilization.Physiological reports · 2022Review
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer.Cancers · 2020Review
- Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics.PLoS computational biology · 2020Article
- Bifurcation in Blood Oscillatory Rhythms for Patients with Ischemic Stroke: A Small Scale Clinical Trial using Laser Doppler Flowmetry and Computational Modeling of Vasomotion.Frontiers in physiology · 2017Article
- Bifurcation study of blood flow control in the kidney.Mathematical biosciences · 2015Article
- Functional sympatholysis and sympathetic escape in a theoretical model for blood flow regulation.Frontiers in physiology · 2014Article
- Capillary recruitment in a theoretical model for blood flow regulation in heterogeneous microvessel networks.Physiological reports · 2013Article
- Theoretical comparison of wall-derived and erythrocyte-derived mechanisms for metabolic flow regulation in heterogeneous microvascular networks.American journal of physiology. Heart and circulatory physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A new theory is presented for the origin of spontaneous oscillations in blood vessel diameters that are observed experimentally in the microcirculation. These oscillations, known as vasomotion, involve timevarying contractions of the vascular smooth muscle in the walls of arterioles. It is shown that such oscillations can arise as a result of interactions between the mechanics of the vessel wall and the dynamics of the active contraction of smooth muscle cells in response to circumferential tension in the wall. A theoretical model is developed in which the diameter and the degree of activation in a vessel are dynamic variables. The model includes effects of wall shear stress and oxygen-dependent metabolic signals on smooth muscle activation and is applied to a single vessel and to simplified network structures. The model equations predict limit cycle oscillations for certain ranges of parameters such as wall shear stress, arterial pressure and oxygen consumption rate. Predicted characteristics of the oscillations, including their sensitivity to arterial pressure, are consistent with experimental observations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.