ArticleThe Journal of biological chemistry2011
Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- Type-1 Ryanodine Receptor Plays an Important Role in Cardiac Hypertrophy and Heart Failure by Increasing Type-2 Ryanodine Receptor-Mediated Calcium Release.International journal of molecular sciences · 2026Article
- Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction.JACC. Basic to translational science · 2025Article
- Review
- Mitochondrial calcium exchange in physiology and disease.Physiological reviews · 2022Review
- Methods of Measuring Mitochondrial Potassium Channels: A Critical Assessment.International journal of molecular sciences · 2022Review
- Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research.Frontiers in physiology · 2022Review
- Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia.Journal of molecular and cellular cardiology · 2021Review
- Targeting mitochondrial ion channels for cancer therapy.Redox biology · 2021Review
- Regulation of Mitochondrial CaAnnual review of physiology · 2021Review
- Why don't mice lacking the mitochondrial CaThe Journal of physiology · 2020Review
- Redox Signaling from Mitochondria: Signal Propagation and Its Targets.Biomolecules · 2020Review
- Role of mitochondrial CaArchives of biochemistry and biophysics · 2019Review
- Slow CaFrontiers in physiology · 2018Article
- The Mitochondrial CaHandbook of experimental pharmacology · 2017Review
- Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.Cardiovascular research · 2016Article
- The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.American journal of physiology. Cell physiology · 2016Review
- UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria.Pflugers Archiv : European journal of physiology · 2015Article
- Modulation of the matrix redox signaling by mitochondrial Ca(2.).World journal of biological chemistry · 2015Review
- Molecular mechanism of mitochondrial calcium uptake.Cellular and molecular life sciences : CMLS · 2015Review
- Mitochondrial calcium transport in trypanosomes.Molecular and biochemical parasitology · 2014Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Heart mitochondria utilize multiple Ca(2+) transport mechanisms. Among them, the mitochondrial ryanodine receptor provides a fast Ca(2+) uptake pathway across the inner membrane to control "excitation and metabolism coupling." In the present study, we identified a novel ryanodine-sensitive channel in the native inner membrane of heart mitochondria and characterized its pharmacological and biophysical properties by directly patch clamping mitoplasts. Four distinct channel conductances of ∼100, ∼225, ∼700, and ∼1,000 picosiemens (pS) in symmetrical 150 mm CsCl were observed. The 225 pS cation-selective channel exhibited multiple subconductance states and was blocked by high concentrations of ryanodine and ruthenium red, known inhibitors of ryanodine receptors. Ryanodine exhibited a concentration-dependent modulation of this channel, with low concentrations stabilizing a subconductance state and high concentrations abolishing activity. The 100, 700, and 1,000 pS conductances exhibited different channel characteristics and were not inhibited by ryanodine. Taken together, these findings identified a novel 225 pS channel as the native mitochondrial ryanodine receptor channel activity in heart mitoplasts with biophysical and pharmacological properties that distinguish it from previously identified mitochondrial ion channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.