Evidence map›Paper›PMID 21524870›Full record

ReviewMagnetic resonance imaging2011

Magnetic resonance in the era of molecular imaging of cancer.

John C Gore, H Charles Manning, C Chad Quarles, Kevin W Waddell, Thomas E Yankeelov

Abstract readReview
In one paragraph

Review in Magnetic resonance imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. MR Imaging Biomarkers in Oncology Clinical Trials.Magnetic resonance imaging clinics of North America · 2016
    Review
  11. Article
  12. Molecular imaging in the era of personalized medicine.Journal of pathology and translational medicine · 2015
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John C GoreVanderbilt University Institute of Imaging Science AA1105 MCN, Vanderbilt University Nashville, TN 37232-2310, USA. john.gore@vanderbilt.edu
H Charles Manning
C Chad Quarles
Kevin W Waddell
Thomas E Yankeelov

Funding

Vanderbilt In Vivo Cellular and Molecular Imaging CenterP50CA128323 · NCI · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2008 to 2012
$6.8M
Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
MRI Diffusion in Tumors Using Oscillating GradientsR01CA109106 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI XU, JUNZHONG · 2006 to 2022
$4.0M
Evaluation and Validation of Imaging Biomarkers of Tumor Response to TreatmentR01CA138599 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MCINTYRE, JAMES OLIVER · 2010 to 2015
$2.2M
South-Eastern Center for Imaging Animal Models of CancerU24CA126588 · NCI · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2007 to 2011
$2.1M
PROTON RELAXATION AND CONTRAST MECHANISMS IN MRIR01EB000214 · NIBIB · YALE UNIVERSITY · PI GORE, JOHN C · 2002 to 2008
$2.1M
Biological Basis of Imaging Biomarkers in Colorectal CancerR01CA140628 · NCI · VANDERBILT UNIVERSITY · PI MANNING, HENRY CHARLES · 2009 to 2013
$1.5M
Evaluation of MRI Biomarkers of Breast Cancer ResponseR01CA129961 · NCI · VANDERBILT UNIVERSITY · PI YANKEELOV, THOMAS E · 2008 to 2011
$1.2M
Molecular Determinants Affecting FLT-PET in Colorectal CancerRC1CA145138 · NCI · VANDERBILT UNIVERSITY · PI MANNING, HENRY CHARLES · 2009 to 2010
$998k
Quantitative MRI Assessment of Tumor Hypoxia and AngiogenesisR00CA127599 · NCI · VANDERBILT UNIVERSITY · PI QUARLES, CHRISTOPHER CHAD · 2008 to 2010
$747k
Assessment of Tumor Early Response to Treatment by Diffusion MRIK25CA168936 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI XU, JUNZHONG · 2013 to 2017
$728k
Synergizing Quantitative HTS Technologies to Guide MIA Discovery and DevelopmentK25CA127349 · NCI · VANDERBILT UNIVERSITY · PI MANNING, HENRY CHARLES · 2008 to 2012
$709k
NCI NIH HHS CA109106NCI NIH HHS CA127349NCI NIH HHS CA127599NCI NIH HHS CA128323NCI NIH HHS CA129961NCI NIH HHS CA138599NCI NIH HHS CA140628NCI NIH HHS CA142565NCI NIH HHS CA145138NCI NIH HHS K25 CA127349NCI NIH HHS K25 CA168936NCI NIH HHS K99 CA127599NCI NIH HHS P50 CA128323NCI NIH HHS R00 CA127599NCI NIH HHS R01 CA109106NCI NIH HHS R01 CA129961NCI NIH HHS R01 CA138599NCI NIH HHS R01 CA140628NCI NIH HHS RC1 CA145138NCI NIH HHS U01 CA142565NCI NIH HHS U24 CA126588NIBIB NIH HHS EB000214NIBIB NIH HHS R01 EB000214
6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) has played an important role in the diagnosis and management of cancer since it was first developed, but other modalities also continue to advance and provide complementary information on the status of tumors. In the future, there will be a major continuing role for noninvasive imaging in order to obtain information on the location and extent of cancer, as well as assessments of tissue characteristics that can monitor and predict treatment response and guide patient management. Developments are currently being undertaken that aim to provide improved imaging methods for the detection and evaluation of tumors, for identifying important characteristics of tumors such as the expression levels of cell surface receptors that may dictate what types of therapy will be effective and for evaluating their response to treatments. Molecular imaging techniques based mainly on radionuclide imaging can depict numerous, specific, cellular and molecular markers of disease and have unique potential to address important clinical and research challenges. In this review, we consider what continuing and evolving roles will be played by MRI in this era of molecular imaging. We discuss some of the challenges for MRI of detecting imaging agents that report on molecular events, but highlight also the ability of MRI to assess other features such as cell density, blood flow and metabolism which are not specific hallmarks of cancer but which reflect molecular changes. We discuss the future role of MRI in cancer and describe the use of selected quantitative imaging techniques for characterizing tumors that can be translated to clinical applications, particularly in the context of evaluating novel treatments.

Indexed as

AnimalsBiomarkers, TumorBrain NeoplasmsBreast NeoplasmsContrast MediaDiagnostic ImagingFemaleHumansMagnetic Resonance ImagingMaleMedical OncologyMembrane ProteinsMolecular ImagingNeoplasmsBiomarkers, TumorContrast MediaMembrane Proteins

Identifiers

PMID21524870
PMCPMC3285504

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.