ArticleBrain research2011
Glycine-activated chloride currents of neurons freshly isolated from the prefrontal cortex of young rats.
Article in Brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits.Life sciences · 2024Article
- Presence of ethanol-sensitive and ethanol-insensitive glycine receptors in the ventral tegmental area and prefrontal cortex in mice.British journal of pharmacology · 2021Article
- Mediatory role of the dopaminergic system through D1 receptor on glycine-induced hypophagia in neonatal broiler-type chickens.Amino acids · 2021Article
- Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens.Frontiers in molecular neuroscience · 2021Article
- Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit.British journal of pharmacology · 2020Article
- Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference.Addiction biology · 2020Article
- Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats.Neuropharmacology · 2019Article
- Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens.Frontiers in molecular neuroscience · 2018Article
- Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Presence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens.The Journal of physiology · 2017Article
- Strychnine-sensitive glycine receptors on pyramidal neurons in layers II/III of the mouse prefrontal cortex are tonically activated.Journal of neurophysiology · 2014Article
- Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Contaminating levels of zinc found in commonly-used labware and buffers affect glycine receptor currents.Brain research bulletin · 2014Article
- Physiological concentrations of zinc reduce taurine-activated GlyR responses to drugs of abuse.Neuropharmacology · 2013Article
- Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Acute effects of ethanol on GABAOpen journal of neuroscience · 2013Article
- Ischemia induces release of endogenous amino acids from the cerebral cortex and cerebellum of developing and adult mice.Journal of amino acids · 2013Article
- Positive allosteric modulators differentially affect full versus partial agonist activation of the glycine receptor.The Journal of pharmacology and experimental therapeutics · 2012Article
- Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption.The Journal of pharmacology and experimental therapeutics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Strychnine-sensitive glycine receptors (GlyR) play a major role in the excitability of CNS neurons and are also a major target of many drugs including some general anesthetics and ethanol. The prefrontal cortex (PFC) is an important substrate responsible for cognitive function and for sedation, as well as hypnosis (unconsciousness) which is induced by general anesthetics and ethanol. However, the functions and the physiological and pharmacological properties of GlyRs in mature PFC neurons have not been well studied. In this study, whole-cell currents induced by glycine (I(Gly)) were recorded from freshly isolated PFC neurons of Sprague-Dawley rats aged 5 to 39 postnatal days (neonatal, P5-12; weanling, P17-21 and peri-adolescent, P30-39). We found that most of the neurons examined were responsive to glycine and the response was concentration dependent. With the increase of age, the sensitivity to glycine was significantly decreased and the sensitivity to picrotoxin was significantly increased. Conversely, the changes in sensitivity to strychnine were not significant. Interestingly, I(Gly) of all age groups was suppressed (to different scope) by low concentrations of picrotoxin (≤ 30 μM), which selectively blocked α homomeric GlyRs. Conversely, about 20-65% of I(Gly) remained in the presence of 300 μM picrotoxin, suggesting the picrotoxin-resistant subtype the αβ heteromeric GlyR, was also present. These data provide the first evidence that there are at least two subtypes of functional GlyRs in the PFC neurons of young rats, and their physiological and pharmacological properties change substantially during maturation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.