ArticleBehavioural brain research2011
Respiratory and sniffing behaviors throughout adulthood and aging in mice.
Article in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- A respiratory signature of disease progression in the Pompe rat.Journal of neurophysiology · 2026Article
- Oscillations in the prefrontal-hippocampal circuit couple to respiration-related oscillations during all phases of a working memory task.Frontiers in behavioral neuroscience · 2025Article
- Olfactory deficits in aging and Alzheimer's-spotlight on inhibitory interneurons.Frontiers in neuroscience · 2024Review
- Intranasal Pressure Recording for Monitoring Mouse Respiration.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies.JCI insight · 2022Article
- Conditional loss of Engrailed1/2 in Atoh1-derived excitatory cerebellar nuclear neurons impairs eupneic respiration in mice.Genes, brain, and behavior · 2022Article
- Gene therapy rescues olfactory perception in a clinically relevant ciliopathy model of Bardet-Biedl syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Deficits in olfactory sensitivity in a mouse model of Parkinson's disease revealed by plethysmography of odor-evoked sniffing.Scientific reports · 2020Article
- Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing.Biology open · 2020Article
- Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex.Brain structure & function · 2019Article
- Plethysmography measurements of respiratory function in conscious unrestrained mice.The journal of physiological sciences : JPS · 2016Article
- Comparing thoracic and intra-nasal pressure transients to monitor active odor sampling during odor-guided decision making in the mouse.Journal of neuroscience methods · 2014Article
- Sequential mechanisms underlying concentration invariance in biological olfaction.Frontiers in neuroengineering · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Orienting responses are physiological and active behavioral reactions evoked by novel stimulus perception and are critical for survival. We explored whether odor orienting responses are impacted throughout both adulthood and normal and pathological aging in mice. Novel odor investigation (including duration and bout numbers) and its subsequent habituation as assayed in the odor habituation task were preserved in adult C57BL/6J mice up to 12 mo of age with <6% variability between age groups in investigation time. Separately, using whole-body plethysmography we found that both spontaneous respiration and odor-evoked sniffing behaviors were strikingly preserved in wildtype (WT) mice up to 26 mo of age. In contrast, mice accumulating amyloid-β protein in the brain by means of overexpressing mutations in the human amyloid precursor protein gene (APP) showed preserved spontaneous respiration up to 12 mo, but starting at 14 mo showed significant differences from WT. Similar to WTs, odor-evoked sniffing was not impacted in APP mice up to 26 mo. These results show that odor-orienting responses are minimally impacted throughout aging in mice, and suggest that the olfactomotor network is mostly spared of insults due to aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.