Trial reportClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2011
Spinal associative stimulation: a non-invasive stimulation paradigm to modulate spinal excitability.
Trial report in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Guideline
- Paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component in treatment of neuropathic pain after incomplete spinal cord injury - a pilot trial.Spinal cord series and cases · 2026Trial
- Paired associative stimulation improves outcomes when applied at the subacute stage after incomplete cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Brain and spinal cord paired stimulation coupled with locomotor training affects polysynaptic flexion reflex circuits in human spinal cord injury.Experimental brain research · 2022Trial
- Failure of spinal paired associative stimulation to induce neuroplasticity in the human corticospinal tract.The journal of spinal cord medicine · 2014Trial
- Movement-generated afference paired with transcranial magnetic stimulation: an associative stimulation paradigm.Journal of neuroengineering and rehabilitation · 2014Trial
- Paired corticospinal-motoneuronal stimulation enhances ballistic motor learning and corticospinal plasticity in older adults.The Journal of physiology · 2026Article
- Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Stable improvement in hand muscle strength in incomplete spinal cord injury patients by long-term paired associative stimulation-a case series study.Frontiers in neurology · 2025Article
- Spinally targeted paired associated stimulation with high-frequency peripheral component induces spinal level plasticity in healthy subjects.Scientific reports · 2024Article
- The effects of music combined to paired associative stimulation on motor-evoked potentials and alertness in spinal cord injury patients and healthy subjects.Scientific reports · 2024Article
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Posteroanterior Cervical Transcutaneous Spinal Cord Stimulation: Interactions with Cortical and Peripheral Nerve Stimulation.Journal of clinical medicine · 2021Article
- A New Paired Associative Stimulation Protocol with High-Frequency Peripheral Component and High-Intensity 20 Hz Repetitive Transcranial Magnetic Stimulation-A Pilot Study.International journal of environmental research and public health · 2021Article
- Training in the practice of noninvasive brain stimulation: Recommendations from an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Review
- Temporal Profile of Descending Cortical Modulation of Spinal Excitability: Group and Individual-Specific Effects.Frontiers in integrative neuroscience · 2021Article
- Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury.Frontiers in neuroscience · 2021Review
- Article
- The Immediate and Short-Term Effects of Transcutaneous Spinal Cord Stimulation and Peripheral Nerve Stimulation on Corticospinal Excitability.Frontiers in neuroscience · 2021Article
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5 authors.
Funding
Abstract
objectiveRepetitive, paired peripheral and transcranial stimulation targeting the cerebral cortex can increase cortical excitability, outlasting the stimulation period. It is unknown whether paired stimulation specifically targeting the spinal cord can modulate spinal excitability. We tested whether the H-reflex facilitation from a sub-threshold conditioning TMS pulse could modulate spinal excitability if delivered repetitively.
methodIn 13 healthy subjects, we delivered single-pulse TMS (80% RMT) for the right soleus muscle, 20 ms prior to an electrical peripheral nerve stimulus delivered over the posterior tibial nerve on the same side at 0.1 Hz during 15 min.
resultsPNS alone evoked an H-reflex of 0.25 mV ± 0.06 SEM, while pairing of TMS and PNS facilitated the H-reflex to 0.7 ± 0.11 mV. TMS-PNS pairs delivered at 0.1 Hz for 15 min progressively increased in the evoked response to ∼130% (r(2) = 0.97) of the starting amplitude (normalized to 1st min). Post-intervention, H-reflex threshold decreased (pre = 12.9 ± 1.7 mA; post =11.6 ± 1.6 mA; p = 0.04), as did the stimulus intensity at maximum H-reflex amplitude (pre = 23.5 ± 02.8 mA; post = 21.6 ± 2.6 mA; p = 0.03), and recruitment curve width (pre = 11.6 ± 1.5 mA; post = 10.93 ± 1.4 mA; p = 0.03). No such changes were observed with intervention of PNS or TMS alone.
conclusionPaired stimulation targeting spinal facilitatory interactions, when applied repetitively, can increase spinal excitability during and after the intervention. SIGNIFICANCE: Spinal associative stimulation may have potential for neuromodulation in spinal cord injury patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.