Evidence map›Paper›PMID 21524578›Full record

ArticleBioorganic & medicinal chemistry letters2011

Macrocyclic chelator assembled RGD multimers for tumor targeting.

Xiaofen Zhang, Hongguang Liu, Zheng Miao, Richard Kimura, Feiyue Fan, Zhen Cheng

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals.Journal of labelled compounds & radiopharmaceuticals · 2014
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Xiaofen ZhangMolecular Imaging Program at Stanford, Department of Radiology, Stanford University Medical Center, California 94305, USA.
Hongguang Liu
Zheng Miao
Richard Kimura
Feiyue Fan
Zhen Cheng
Stanford Medicine · USStanford University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNTsinghua University · CN

Funding

Radiolabeled RGD Peptides for Breast Cancer Imaging and TherapyR01CA119053 · NCI · STANFORD UNIVERSITY · PI CHENG, ZHEN · 2007 to 2010
$952k
NCI NIH HHS R01 CA119053
6 · The paper itself

Abstract

Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability.

Indexed as

Drug Delivery SystemsMacrocyclic CompoundsNeoplasmsAnimalsChelating AgentsDiagnostic ImagingHeterocyclic Compounds, 1-RingMiceMolecular StructureOligopeptides1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidarginyl-glycyl-aspartic acidChelating AgentsHeterocyclic Compounds, 1-RingMacrocyclic CompoundsOligopeptides

Identifiers

PMID21524578
PMCPMC3098922
OpenAlexW1972714699

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.