Evidence map›Paper›PMID 21524302›Full record

ArticleBMC ecology2011

Simrank: Rapid and sensitive general-purpose k-mer search tool.

Todd Z DeSantis, Keith Keller, Ulas Karaoz, Alexander V Alekseyenko, Navjeet N S Singh, Eoin L Brodie, Zhiheng Pei, Gary L Andersen, Niels Larsen

Abstract read
In one paragraph

Article in BMC ecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  7. Comparative genomics of oral isolates of Streptococcus mutans by in silico genome subtraction does not reveal accessory DNA associated with severe early childhood caries.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Todd Z DeSantisEcology Department, Lawrence Berkeley National Laboratory, Berkeley, USA. tdesantis@lbl.gov
Keith Keller
Ulas Karaoz
Alexander V Alekseyenko
Navjeet N S Singh
Eoin L Brodie
Zhiheng Pei
Gary L Andersen
Niels Larsen

Funding

A Quality Assurance, Coordination and Analysis Center for HMPU01HG004866 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI WHITE, OWEN R · 2008 to 2012
$12.5M
Resequencing microarray for rapid detection & antimicrobial resistance profilingU01AI075410 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LYNCH, SUSAN VERONICA · 2007 to 2011
$3.5M
Foregut microbiome in development of esophageal adenocarcinomaUH2CA140233 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NELSON, KAREN E., PEI, ZHIHENG · 2009 to 2009
$1.1M
NCI NIH HHS UH2/UH3CA140233NHGRI NIH HHS U01-HG004866NIAID NIH HHS AI075410-01
6 · The paper itself

Abstract

backgroundTerabyte-scale collections of string-encoded data are expected from consortia efforts such as the Human Microbiome Project http://nihroadmap.nih.gov/hmp. Intra- and inter-project data similarity searches are enabled by rapid k-mer matching strategies. Software applications for sequence database partitioning, guide tree estimation, molecular classification and alignment acceleration have benefited from embedded k-mer searches as sub-routines. However, a rapid, general-purpose, open-source, flexible, stand-alone k-mer tool has not been available.

resultsHere we present a stand-alone utility, Simrank, which allows users to rapidly identify database strings the most similar to query strings. Performance testing of Simrank and related tools against DNA, RNA, protein and human-languages found Simrank 10X to 928X faster depending on the dataset.

conclusionsSimrank provides molecular ecologists with a high-throughput, open source choice for comparing large sequence sets to find similarity.

Indexed as

Databases, BibliographicDatabases, FactualMolecular BiologySoftwareComputational BiologyDNAProteinsRNADNAProteinsRNA

Identifiers

PMID21524302
PMCPMC3097142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.