ArticleJournal of molecular modeling2012
Fuzzy oil drop model to interpret the structure of antifreeze proteins and their mutants.
Article in Journal of molecular modeling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Three scenarios for amyloid transformation in the context of the funnel model.Computational and structural biotechnology journal · 2025Article
- Article
- Towards the design of anti-amyloid short peptide helices.Bioinformation · 2018Article
- Is the hydrophobic core a universal structural element in proteins?Journal of molecular modeling · 2017Article
- Article
- Structural Interface Forms and Their Involvement in Stabilization of Multidomain Proteins or Protein Complexes.International journal of molecular sciences · 2016Article
- Statistical dictionaries for hypothetical in silico model of the early-stage intermediate in protein folding.Journal of computer-aided molecular design · 2015Article
- Hypothetical in silico model of the early-stage intermediate in protein folding.Journal of molecular modeling · 2013Article
- Intermediates in the protein folding process: a computational model.International journal of molecular sciences · 2011Article
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Authors and funding
5 authors.
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Abstract
Mutations in proteins introduce structural changes and influence biological activity: the specific effects depend on the location of the mutation. The simple method proposed in the present paper is based on a two-step model of in silico protein folding. The structure of the first intermediate is assumed to be determined solely by backbone conformation. The structure of the second one is assumed to be determined by the presence of a hydrophobic center. The comparable structural analysis of the set of mutants is performed to identify the mutant-induced structural changes. The changes of the hydrophobic core organization measured by the divergence entropy allows quantitative comparison estimating the relative structural changes upon mutation. The set of antifreeze proteins, which appeared to represent the hydrophobic core structure accordant with "fuzzy oil drop" model was selected for analysis.
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