Evidence map›Paper›PMID 21523523›Full record

ArticleNeurocritical care2011

The ketogenic diet for medically and surgically refractory status epilepticus in the neurocritical care unit.

Mackenzie C Cervenka, Adam L Hartman, Arun Venkatesan, Romergryko G Geocadin, Eric H Kossoff

2 registry-linked trialsOpen access · bronzeAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01796574 nacompletednot on this mapstarted 2012, after this paper: background citation

Feasibility and Tolerability of the Ketogenic Diet in the Treatment of Refractory Status Epilepticus in a Neurointensive Care Unit.

TypeinterventionalSponsorJohns Hopkins UniversityRan2012 to 2017Enrolled15ConditionsStatus Epilepticus, Seizure, Epilepsy, Refractory Status EpilepticusArmsKetogenic diet
NCT04358835 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)

TypeinterventionalSponsorJohns Hopkins UniversityRan2020 to 2021Enrolled0ConditionsCOVID-19ArmsKetogenic diet, standard of care
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  15. Updates in Refractory Status Epilepticus.Critical care research and practice · 2018
    Review
  16. Article
  17. Review
  18. Article
  19. Dietary treatment of intractable epilepsy.Continuum (Minneapolis, Minn.) · 2013
    Review
  20. Treatment of Generalized Convulsive Status Epilepticus in Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mackenzie C CervenkaDepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Meyer 2-147, Baltimore, MD 21287-7247, USA. mcerven1@jhmi.edu
Adam L Hartman
Arun Venkatesan
Romergryko G Geocadin
Eric H Kossoff
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRefractory status epilepticus carries a high risk of morbidity and mortality despite, and at times as a result of, aggressive pharmacologic interventions. Dietary therapies have been used for almost a century in children for controlling medically refractory seizures and status epilepticus and recent studies suggest efficacy and safety in adults as well.

methodsCase report and literature review.

resultsWe describe a case of medically and surgically refractory status epilepticus that was controlled after initiation of the ketogenic diet and maintenance with the modified Atkins diet in an adult in the neurocritical care unit.

conclusionsDietary therapy should be considered as a treatment option in adult patients with refractory status epilepticus.

Indexed as

Diet, KetogenicIntensive Care UnitsAnticonvulsantsCombined Modality TherapyElectroencephalographyEncephalomalaciaEnteral NutritionEpilepsy, Complex PartialFrontal LobeGliosisHumansMagnetic Resonance ImagingMaleMiddle AgedSignal Processing, Computer-AssistedStatus EpilepticusAnticonvulsants

Identifiers

PMID21523523
OpenAlexW2071085267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.