Evidence map›Paper›PMID 21523258›Full record

ReviewCanadian journal of gastroenterology = Journal canadien de gastroenterologie2011

Collagenous sprue.

Hugh James Freeman

Open access · goldAbstract readReview
In one paragraph

Review in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 52 citations in OpenAlex.

  1. Non-celiac Enteropathies.Current gastroenterology reports · 2025
    Review
  2. Collagenous sprue: a rare cause of watery diarrhea and villous atrophy - case report.Gastroenterology and hepatology from bed to bench · 2023
    Article
  3. Review
  4. Article
  5. Clinical and Histologic Mimickers of Celiac Disease.Clinical and translational gastroenterology · 2017
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hugh James FreemanDepartment of Medicine and Pathology, University of British Columbia, Vancouver, British Columbia. hughfree@shaw.ca
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collagenous sprue is a small bowel mucosal lesion that has been historically associated with persistent diarrhea, progressive weight loss and severe malabsorption causing multiple nutrient deficiencies. A severe to variably severe mucosal lesion with distinct subepithelial collagen deposits occurs. Celiac disease has been intimately linked to collagenous sprue and, similar to celiac disease, small bowel ulceration, perforation and lymphoma may complicate the clinical course of collagenous sprue. In collagenous sprue, concomitant collagen deposits may also occur in gastric or colonic mucosal sites (or both), indicating that this unusual mucosal process may be very heterogeneous and far more extensive in the intestinal tract than previously appreciated. Moreover, reports of diagnosis during infancy suggest that the natural history of the disorder could be more prolonged than is currently appreciated. Finally, the collagen deposits, per se, may be due to different causes and, in some, even represent a novel paraneoplastic histopathological marker. Future studies are needed to more precisely define molecular and genetic biomarkers that identify homogeneous groups and permit the development of improved treatment strategies for this increasingly recognized disorder.

Indexed as

Celiac DiseaseAdrenal Cortex HormonesCollagenDiarrheaDiet, Gluten-FreeDisease-Free SurvivalDisease ProgressionDrug Therapy, CombinationHumansImmunosuppressive AgentsIntestinal AbsorptionIntestinal MucosaIntestine, SmallMalnutritionWeight LossAdrenal Cortex HormonesCollagenImmunosuppressive Agents

Identifiers

PMID21523258
PMCPMC3088692
OpenAlexW4235933252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.