Evidence map›Paper›PMID 21522191›Full record

ReviewNature reviews. Microbiology2011

Subversion of the actin cytoskeleton during viral infection.

Matthew P Taylor, Orkide O Koyuncu, Lynn W Enquist

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers.

0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

235 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Pathogen-Mediated Cell Fusion and Actin Cytoskeleton.Advances in experimental medicine and biology · 2026
    Review
  10. Basic Virology.Advances in experimental medicine and biology · 2026
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Mechanoregulation of lymphocyte cytotoxicity.Nature reviews. Immunology · 2025
    Review
  16. Exploring Therapeutic Targets From Spreading Patterns Against Respiratory Syncytial Virus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  17. Article
  18. Article
  19. Host centric drug repurposing for viral diseases.PLoS computational biology · 2025
    Article
  20. Article

175 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew P TaylorDepartment of Molecular Biology, Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA.
Orkide O Koyuncu
Lynn W Enquist

Funding

Genetic Analysis of Herpesvirus Tropism and VirulenceR37NS033506 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 2005 to 2020
$4.1M
GENETIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCER01NS033506 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 1995 to 2016
$3.7M
Neuronal Spread of Herpesvirus InfectionR01NS060699 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 2008 to 2017
$3.6M
NINDS NIH HHS R01 NS033506NINDS NIH HHS R01 NS060699NINDS NIH HHS R37 NS033506
6 · The paper itself

Abstract

Viral infection converts the normal functions of a cell to optimize viral replication and virion production. One striking observation of this conversion is the reconfiguration and reorganization of cellular actin, affecting every stage of the viral life cycle, from entry through assembly to egress. The extent and degree of cytoskeletal reorganization varies among different viral infections, suggesting the evolution of myriad viral strategies. In this Review, we describe how the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections. The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell.

Indexed as

ActinsAdenoviridaeAnimalsCell Transformation, ViralCytoskeletonEndocytosisHepatitis B virusHerpesviridaeHumansrho GTP-Binding ProteinsRous sarcoma virusSimian virus 40Viral ProteinsVirionVirus AssemblyVirus ReplicationActinsrho GTP-Binding ProteinsViral Proteins

Identifiers

PMID21522191
PMCPMC3229036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.