ArticleBehavioural pharmacology2011
False positive in the intravenous drug self-administration test in C57BL/6J mice.
Article in Behavioural pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.Neuropharmacology · 2025Article
- Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options.Pharmacology, biochemistry, and behavior · 2024Review
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.bioRxiv : the preprint server for biology · 2024Article
- Ameliorating effects of Acanthopanax koreanum extract and components on nicotine dependence and withdrawal symptoms.Addiction biology · 2024Article
- Deletion ofFrontiers in pharmacology · 2023Article
- Jugular Vein Catheter Design and Cocaine Self-Administration Using Mice: A Comprehensive Method.Frontiers in behavioral neuroscience · 2022Article
- Fentanyl-induced acute and conditioned behaviors in two inbred mouse lines: Potential role for Glyoxalase.Physiology & behavior · 2022Article
- An optimized procedure for robust volitional cocaine intake in mice.Experimental and clinical psychopharmacology · 2021Article
- Fentanyl vapor self-administration model in mice to study opioid addiction.Science advances · 2020Article
- β-Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents.British journal of pharmacology · 2020Article
- Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning.Genes, brain, and behavior · 2019Article
- Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine.Psychopharmacology · 2018Article
- Effects of muscarinic MPsychopharmacology · 2018Article
- Muscarinic receptor MDrug and alcohol dependence · 2017Article
- Effects of the GLP-1 Agonist Exendin-4 on Intravenous Ethanol Self-Administration in Mice.Alcoholism, clinical and experimental research · 2016Article
- Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice.Psychopharmacology · 2015Article
- Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons.The international journal of neuropsychopharmacology · 2014Article
- Effects of adolescent nicotine exposure and withdrawal on intravenous cocaine self-administration during adulthood in male C57BL/6J mice.Addiction biology · 2014Article
- Cocaine self-administration behavior in inbred mouse lines segregating different capacities for inhibitory control.Psychopharmacology · 2013Article
- Cocaine-related behaviors in mice with deficient gliotransmission.Psychopharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of this study was to examine C57BL/6J (B6) mice during extinction conditions, after food training, and for rates and patterns of operant behavior that seems similar to behavior maintained by intravenous cocaine injections. The rationale was to evaluate the potential for false positives in the intravenous self-administration test using protocols common in studies of knockout mice backcrossed to B6. An additional aim was to assess the influence of food-associated and drug-associated cues and mouse strain. Mice were allowed to acquire lever pressing reinforced by sweetened condensed milk under a fixed ratio 1 then fixed ratio 2 schedule of reinforcement accompanied by a flashing light. A catheter base was then implanted for simulation of intravenous self-administration conditions. Mice were allowed to lever press with cues remaining the same as during food training but without further scheduled consequences (i.e. no drug or food reinforcers delivered). All mice sustained lever pressing for several weeks, and over half met commonly used criteria for 'self-administration behavior.' Thus, B6 mice showed perseveration of a previously reinforced behavior that closely resembled rates and patterns of drug self-administration. This effect in B6 mice was greater than with A/J mice, and the lack of extinction was even more robust in the presence of cocaine-associated cues than with food-associated cues. We suggest that a necessary criterion for positive results in the intravenous drug self-administration test include an increase in responding when cocaine is made available after extinction with saline self-administration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.