ArticleEpigenetics2011
Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta.
Article in Epigenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 161 citations in OpenAlex.
- A Systematic Review of DNA Methylation and Preterm Birth in African American Women.Biological research for nursing · 2017Pooled it
- Trial
- DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases.Clinical epigenetics · 2020Trial
- Maternal epigenetic signatures are associated with small for gestational age births among black women.Epigenetics insights · 2026Article
- Stress, Well-Being, and Reproduction in Wildlife.Advances in experimental medicine and biology · 2026Review
- Bone mineralization in children aged 7-10 years born after ART with frozen and fresh embryo transfer.Human reproduction open · 2025Article
- Increased levels of DNA methyltransferases in the placentas of women affected by Placenta Accreta Spectrum lead to aberrant DNA methylation patterns.Journal of molecular histology · 2024Article
- Combining Transcriptomics and Proteomics to Screen Candidate Genes Related to Bovine Birth Weight.Animals : an open access journal from MDPI · 2024Article
- Associations between placental hydroxymethylation and birthweight.Epigenetics reports · 2024Article
- Postnatal levels of glycated albumin and glycated hemoglobin A1c in mothers of large-for-gestational-age newborns.Frontiers in pediatrics · 2024Article
- Article
- Extensive Placental Methylation Profiling in Normal Pregnancies.International journal of molecular sciences · 2021Article
- Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation.Scientific reports · 2020Article
- Epigenetic biomarkers and preterm birth.Environmental epigenetics · 2020Review
- Maternal body mass index change as a new optimal gestational weight gain predictor in overweight women.Croatian medical journal · 2019Observational
- Steroid receptors and their regulation in avian extraembryonic membranes provide a novel substrate for hormone mediated maternal effects.Scientific reports · 2019Article
- Epigenetic Programming and Fetal Metabolic Programming.Frontiers in endocrinology · 2019Review
- Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment.Frontiers in endocrinology · 2019Review
- Sex Differences in Nutrition, Growth, and Metabolism in Preterm Infants.Frontiers in pediatrics · 2019Review
- Adverse Maternal Metabolic Intrauterine Environment and Placental Epigenetics: Implications for Fetal Metabolic Programming.Current environmental health reports · 2018Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Birthweight has been associated with a number of health outcomes throughout life. Crucial to proper infant growth and development is the placenta, and alterations to placental gene function may reflect differences in the intrauterine environment which functionally contribute to infant growth and may ultimately affect the child's health. To examine if epigenetic alteration to the glucocorticoid receptor (GR) gene was linked to infant growth, we analyzed 480 human placentas for differential methylation of the GR gene exon 1F and examined how this variation in methylation extent was associated with fetal growth. Multivariable linear regression revealed a significant association (p < 0.0001) between differential methylation of the GR gene and large for gestational age (LGA) status. Our work is one of the first to link infant growth as a measure of the intrauterine environment and epigenetic alterations to the GR and suggests that DNA methylation may be a critical determinant of placental function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.