ArticleThe Journal of biological chemistry2011
Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Biomarkers of Pesticide Exposure in a Traditional Brazilian Amazon Community.International journal of environmental research and public health · 2024Article
- Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans.Nature communications · 2022Article
- Negative feedback-loop mechanisms regulating HOG- and pheromone-MAPK signaling in yeast.Current genetics · 2020Review
- Regulation of large and small G proteins by ubiquitination.The Journal of biological chemistry · 2019Review
- G protein subunit phosphorylation as a regulatory mechanism in heterotrimeric G protein signaling in mammals, yeast, and plants.The Biochemical journal · 2018Review
- An Antimicrobial Peptide InducesFrontiers in microbiology · 2018Article
- Mitogen-activated protein kinases, Fus3 and Kss1, regulate chronological lifespan in yeast.Aging · 2017Article
- Amino acid metabolites that regulate G protein signaling during osmotic stress.PLoS genetics · 2017Article
- Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells.Oncotarget · 2017Article
- Direct Modulation of Heterotrimeric G Protein-coupled Signaling by a Receptor Kinase Complex.The Journal of biological chemistry · 2016Article
- Structural Analysis of PTM Hotspots (SAPH-ire)--A Quantitative Informatics Method Enabling the Discovery of Novel Regulatory Elements in Protein Families.Molecular & cellular proteomics : MCP · 2015Article
- Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition.Cell · 2015Article
- Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast.The Journal of biological chemistry · 2014Article
- Regulation of yeast G protein signaling by the kinases that activate the AMPK homolog Snf1.Science signaling · 2013Article
- Signaling crosstalk: integrating nutrient availability and sex.Science signaling · 2013Article
- Protons as second messenger regulators of G protein signaling.Molecular cell · 2013Article
- An acid test for g proteins.Molecular cell · 2013Article
- Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression.Molecular cell · 2012Article
- Signal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signaling.Science signaling · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A diverse array of external stimuli, including most hormones and neurotransmitters, bind to cell surface receptors that activate G proteins. Mating pheromones in yeast Saccharomyces cerevisiae activate G protein-coupled receptors and initiate events leading to cell cycle arrest in G(1) phase. Here, we show that the Gα subunit (Gpa1) is phosphorylated and ubiquitinated in response to changes in the cell cycle. We systematically screened 109 gene deletion strains representing the non-essential yeast kinome and identified a single kinase gene, ELM1, as necessary and sufficient for Gpa1 phosphorylation. Elm1 is expressed in a cell cycle-dependent manner, primarily at S and G(2)/M. Accordingly, phosphorylation of Gpa1 in G(2)/M phase leads to polyubiquitination in G(1) phase. These findings demonstrate that Gpa1 is dynamically regulated. More broadly, they reveal how G proteins can simultaneously regulate, and become regulated by, progression through the cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.