ArticleMolecular imaging2011
Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results.
Article in Molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- A multi-pulse ultrasound technique for imaging of thick-shelled microbubbles demonstrated in vitro and in vivo.PloS one · 2022Article
- Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models.Molecular imaging and biology · 2017Article
- The Use of Acoustic Radiation Force Decorrelation-Weighted Pulse Inversion for Enhanced Ultrasound Contrast Imaging.Investigative radiology · 2017Article
- Pipe Phantoms With Applications in Molecular Imaging and System Characterization.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Article
- Feasibility of A-mode ultrasound attenuation as a monitoring method of local hyperthermia treatment.Medical & biological engineering & computing · 2016Article
- Molecular Acoustic Angiography: A New Technique for High-resolution Superharmonic Ultrasound Molecular Imaging.Ultrasound in medicine & biology · 2016Article
- Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles.Annals of biomedical engineering · 2015Article
- Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results.Investigative radiology · 2015Article
- Ultrasound-based measurement of molecular marker concentration in large blood vessels: a feasibility study.Ultrasound in medicine & biology · 2015Article
- Localized in vivo model drug delivery with intravascular ultrasound and microbubbles.Ultrasound in medicine & biology · 2014Article
- Characterization of the dynamic activities of a population of microbubbles driven by pulsed ultrasound exposure in sonoporation.Ultrasound in medicine & biology · 2014Article
- An IVUS transducer for microbubble therapies.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2014Article
- Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis.Imaging in medicine · 2014Article
- Binding dynamics of targeted microbubbles in response to modulated acoustic radiation force.Physics in medicine and biology · 2014Article
- Contrast-enhanced imaging of SPIO-labeled platelets using magnetomotive ultrasound.Physics in medicine and biology · 2013Article
- Improving ultrasound gene transfection efficiency by controlling ultrasound excitation of microbubbles.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Shear forces from flow are responsible for a distinct statistical signature of adherent microbubbles in large vessels.Molecular imaging · 2013Article
- MR-guided focused ultrasound surgery, present and future.Medical physics · 2013Review
- Intravascular near-infrared fluorescence catheter with ultrasound guidance and blood attenuation correction.Journal of biomedical optics · 2013Article
- Acoustic radiation force for vascular cell therapy: in vitro validation.Ultrasound in medicine & biology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Ultrasound-based molecular imaging employs targeted microbubbles to image vascular pathology. This approach also has the potential to monitor molecularly targeted microbubble-based drug delivery. We present an image-guided drug delivery technique that uses multiple pulses to translate, image, and cavitate microbubbles in real time. This technique can be applied to both imaging of pathology in large arteries (sizes and flow comparable to those in humans) and guiding localized drug delivery in blood vessels. The microbubble translation (or pushing) efficacy of this technique was compared in a variety of flow media: saline, viscous saline (4 cp), and bovine blood. It was observed that the performance of this approach was marginally better (by 6, 4, and 2 dB) in viscous saline than in bovine blood with varying levels of hematocrit (40%, 30%, and 10%). The drug delivery efficacy of this technique was evaluated by in vitro and ex vivo experiments. High-intensity pulses mediated fluorophore (DiI) deposition on endothelial cells (in vitro) without causing cell destruction. Ex vivo fluorophore delivery experiments conducted on swine carotids of 2 and 5 mm cross-section diameter demonstrated a high degree of correspondence in spatial localization of the fluorophore delivery between the ultrasound and composite fluorescence microscopy images of the arterial cross sections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.