ArticleBiomedical engineering online2011
Comparison of morphological changes in efferent lymph nodes after implantation of resorbable and non-resorbable implants in rabbits.
Article in Biomedical engineering online, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology--a systematic review.BMC veterinary research · 2013Pooled it
- Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices.Advanced healthcare materials · 2026Review
- Immunological reaction to magnesium-based implants for orthopedic applications. What do we know so far? A systematic review onMaterials today. Bio · 2022Review
- Cytocompatibility and early inflammatory response of human endothelial cells in direct culture with Mg-Zn-Sr alloys.Acta biomaterialia · 2017Article
- Magnesium corrosion particles do not interfere with the immune function of primary human and murine macrophages.Progress in biomaterials · 2015Article
- Ligation of the spermatic cord in dogs with a self-locking device of a resorbable polyglycolic based co-polymer--feasibility and long-term follow-up study.BMC research notes · 2014Article
- Magnesium alloys as a biomaterial for degradable craniofacial screws.Acta biomaterialia · 2014Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMagnesium alloys as biodegradable implant materials received much interest in recent years. It is known that products of implant degradation can induce several types of immune response. Hence, the aim of this study was to examine the morphological changes of efferent lymph nodes after implantation of different resorbable magnesium alloys (MgCa0.8, LAE442) in comparison to commercially available resorbable (PLA) and non-resorbable (titanium) implant materials as well as control groups without implant material.
methodsThe different implant materials were inserted intramedullary into the rabbit tibia. After postoperative observation periods of three and six months, popliteal lymph nodes were examined histologically and immunhistologically and compared to lymph nodes of sham operated animals and animals without surgery. Haematoxylin and eosin staining was performed for cell differentiation. Mouse anti-CD79α and rat anti-CD3 monoclonal primary antibodies were used for B- and T-lymphocyte detection, mouse anti-CD68 primary antibodies for macrophage detection. Evaluation of all sections was performed applying a semi quantitative score.
resultsThe histological evaluation demonstrated low and moderate levels of morphological changes for both magnesium alloys (LAE442 and MgCa0.8). Higher than moderate values were reached for titanium in sinus histiocytosis and histiocytic apoptosis (3 months) and for PLA in histiocytic apoptosis (3 and 6 months). The immune response to all investigated implants had a non-specific character and predominantly was a foreign-body reaction. LAE442 provoked the lowest changes which might be due to a lower degradation rate in comparison to MgCa0.8. Therewith it is a promising candidate for implants with low immunogenic potential.
conclusionBoth examined magnesium alloys did not cause significantly increased morphological changes in efferent lymph nodes in comparison to the widely used implant materials titanium and PLA. LAE442 induced even lower immunological reactions. Therewith MgCa0.8 and especially LAE442 are appropriate candidates for biomedical use.
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