ArticleFEMS microbiology letters2011
Transcriptional repressor Rex is involved in regulation of oxidative stress response and biofilm formation by Streptococcus mutans.
Article in FEMS microbiology letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 70 citations in OpenAlex.
- An XRE-type regulator inMicrobiology spectrum · 2026Article
- Adaptive transcriptional remodeling ofNpj complexity · 2026Article
- SppR inFrontiers in cellular and infection microbiology · 2026Article
- The invasive GAS puzzle in Italy: genomic insights from a hospital cohort in a fragmented surveillance landscape.Frontiers in cellular and infection microbiology · 2025Article
- Impacts of a DUF2207 Family Protein onMicroorganisms · 2023Article
- Adaptation to simulated microgravity in Streptococcus mutans.NPJ microgravity · 2022Article
- Structural Basis of Redox-Sensing Transcriptional Repressor Rex with Cofactor NADInternational journal of molecular sciences · 2022Article
- Diaryl Urea Derivative Molecule Inhibits CariogenicFrontiers in cellular and infection microbiology · 2022Article
- Is hyaluronic acid production transcriptionally regulated? A transcriptional repressor gene deletion study in Streptococcus zooepidemicus.Applied microbiology and biotechnology · 2021Article
- Inhibition of Streptococcus mutans biofilms with bacterial-derived outer membrane vesicles.BMC microbiology · 2021Article
- How Bacterial Redox Sensors Transmit Redox Signals via Structural Changes.Antioxidants (Basel, Switzerland) · 2021Review
- Genome-Wide Transcription Factor DNA Binding Sites and Gene Regulatory Networks inFrontiers in microbiology · 2021Article
- Article
- Azalomycin FInternational journal of molecular sciences · 2020Article
- Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci.Microbiology and molecular biology reviews : MMBR · 2019Review
- Rex in Caldicellulosiruptor bescii: Novel regulon members and its effect on the production of ethanol and overflow metabolites.MicrobiologyOpen · 2019Article
- Deficiency of BrpA in Streptococcus mutans reduces virulence in rat caries model.Molecular oral microbiology · 2018Article
- Differential oxidative stress tolerance of Streptococcus mutans isolates affects competition in an ecological mixed-species biofilm model.Environmental microbiology reports · 2018Article
- NADH-Mediated Gene Expression inFrontiers in microbiology · 2018Article
- The redox-sensing protein Rex modulates ethanol production in Thermoanaerobacterium saccharolyticum.PloS one · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The transcriptional repressor Rex has been implicated in the regulation of energy metabolism and fermentative growth in response to redox potential. Streptococcus mutans, the primary causative agent of human dental caries, possesses a gene that encodes a protein with high similarity to members of the Rex family of proteins. In this study, we showed that Rex-deficiency compromised the ability of S. mutans to cope with oxidative stress and to form biofilms. The Rex-deficient mutant also accumulated less biofilm after 3 days than the wild-type strain, especially when grown in sucrose-containing medium, but produced more extracellular glucans than the parental strain. Rex-deficiency caused substantial alterations in gene transcription, including those involved in heterofermentative metabolism, NAD(+) regeneration and oxidative stress. Among the upregulated genes was gtfC, which encodes glucosyltransferase C, an enzyme primarily responsible for synthesis of water-insoluble glucans. These results reveal that Rex plays an important role in oxidative stress responses and biofilm formation by S. mutans.
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Registered trials
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