ArticlePediatric pulmonology2011
Relation of early childhood growth and wheezing phenotypes to adult lung function.
Article in Pediatric pulmonology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction.American journal of respiratory and critical care medicine · 2018Review
- The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review.Pediatric pulmonology · 2017Review
- Key paediatric messages from Amsterdam.ERJ open research · 2016Article
- Viral infections and the development of asthma in children.Therapeutic advances in infectious disease · 2013Review
- Validation of novel wheeze phenotypes using longitudinal airway function and atopic sensitization data in the first 6 years of life: evidence from the Southampton Women's survey.Pediatric pulmonology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleSeveral studies have reported associations between indicators of birth size and postnatal growth rates with levels of pulmonary function achieved as adults. The objective of this study was to determine if levels and/or rates of weight gain, measured in early life (birth-6 years), are associated with FVC or FEV1 levels achieved in young adulthood and if these associations differ by early childhood wheezing phenotypes.
methodsWe used data from participants in the Tucson Children's Respiratory Study (CRS), a prospective birth cohort study. Weight was measured quarterly up to age 3 years and again at age 6 years. Pulmonary function was assessed at ages 16 and 22. Mean weight and slope of weight growth between 3 and 6 years were estimated using standardized residuals. Longitudinal models were used to determine predictors of FVC and FEV1 at ages 16 and 22 years.
resultsThere were 127 non-Hispanic white subjects that had at least four weight measures and one or more pulmonary function measures as young adults. After adjusting for sex, height, and age, the standardized slope of weight growth (between 3 and 6 years) was positively associated with higher levels of FVC at age 16 and 22 years (P = 0.0001) among subjects who did not have preschool wheezing. However, this association was completely absent among subjects who had wheezing lower respiratory tract illnesses in the first 3 years of life. Similar trends were found for FEV1.
conclusionThe rate of weight gain between 3 and 6 years is significantly positively related to adult FVC and FEV1 and this association is modified by early wheezy phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.