ArticleHuman brain mapping2012
Contextual interaction between novelty and reward processing within the mesolimbic system.
Article in Human brain mapping, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Can guidance during play enhance children's learning and development in educational contexts? A systematic review and meta-analysis.Child development · 2022Pooled it
- Dopamine effects on evidence gathering and integration.Journal of psychiatry & neuroscience : JPN · 2015Trial
- Dopaminergic modulation of probabilistic reasoning and overconfidence in errors: a double-blind study.Schizophrenia bulletin · 2014Trial
- Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory.Nature communications · 2025Article
- Concurrent representations of reinstated and transformed memories and their modulation by reward.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Playful brains: a possible neurobiological pathway to cognitive health in aging.Frontiers in human neuroscience · 2025Article
- Perirhinal cortex to the nucleus accumbens circuit in novelty salience following methamphetamine self-administration.Addiction neuroscience · 2024Article
- Which intellectual activities are related to cognitive reserve? Introduction and testing a three-dimensional model.Psychological research · 2024Article
- Broad brain networks support curiosity-motivated incidental learning of naturalistic dynamic stimuli with and without monetary incentives.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Reduction in the activity of VTA/SNc dopaminergic neurons underlies aging-related decline in novelty seeking.Communications biology · 2023Article
- Differential effects of expectancy on memory formation in young and older adults.Human brain mapping · 2023Article
- A reward effect on memory retention, consolidation, and generalization?Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Functional lateralization of the medial temporal lobe in novel associative processing during creativity evaluation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023Review
- Reward, motivation and brain imaging in human healthy participants - A narrative review.Frontiers in behavioral neuroscience · 2023Review
- Category-specific memory encoding in the medial temporal lobe and beyond: the role of reward.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- A bias toward the unknown: individual and environmental factors influencing exploratory behavior.Annals of the New York Academy of Sciences · 2022Article
- Human complex exploration strategies are enriched by noradrenaline-modulated heuristics.eLife · 2021Article
- Midbrain circuits of novelty processing.Neurobiology of learning and memory · 2020Review
- The effect of intrinsic and extrinsic motivation on memory formation: insight from behavioral and imaging study.Brain structure & function · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Medial temporal lobe (MTL) dependent long-term memory for novel events is modulated by a circuitry that also responds to reward and includes the ventral striatum, dopaminergic midbrain, and medial orbitofrontal cortex (mOFC). This common neural network may reflect a functional link between novelty and reward whereby novelty motivates exploration in the search for rewards; a link also termed novelty "exploration bonus." We used fMRI in a scene encoding paradigm to investigate the interaction between novelty and reward with a focus on neural signals akin to an exploration bonus. As expected, reward related long-term memory for the scenes (after 24 hours) strongly correlated with activity of MTL, ventral striatum, and substantia nigra/ventral tegmental area (SN/VTA). Furthermore, the hippocampus showed a main effect of novelty, the striatum showed a main effect of reward, and the mOFC signalled both novelty and reward. An interaction between novelty and reward akin to an exploration bonus was found in the hippocampus. These data suggest that MTL novelty signals are interpreted in terms of their reward-predicting properties in the mOFC, which biases striatal reward responses. The striatum together with the SN/VTA then regulates MTL-dependent long-term memory formation and contextual exploration bonus signals in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.