ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2011
Feasibility of subendocardial and subepicardial myocardial perfusion measurements in healthy normals with (15)O-labeled water and positron emission tomography.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Evaluation of non-invasive imaging parameters in coronary microvascular disease: a systematic review.BMC medical imaging · 2021Pooled it
- Subendocardial quantification enhances coronary artery disease detection inEuropean journal of nuclear medicine and molecular imaging · 2025Trial
- Coronary Microvascular Dysfunction Is Associated With Myocardial Ischemia and Abnormal Coronary Perfusion During Exercise.Circulation · 2019Trial
- Transmural myocardial perfusion gradients in relation to coronary artery stenoses severity assessed by cardiac multidetector computed tomography.The international journal of cardiovascular imaging · 2015Trial
- A Poroelastic Computational Modeling Framework Coupling Left Ventricular Cardiac Mechanics and Myocardial Perfusion.International journal for numerical methods in biomedical engineering · 2026Article
- The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Relationship of Subendocardial Perfusion to Myocardial Injury, Cardiac Structure, and Clinical Outcomes Among Patients With Hypertension.Circulation · 2024Observational
- Coronary Sinus Reducer Therapy for Refractory Angina and its Role in Modern Interventional Practice: A Contemporary Review.Interventional cardiology (London, England) · 2024Review
- Sub-endocardial and sub-epicardial measurement of myocardial blood flow usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Observational
- Inline perfusion mapping provides insights into the disease mechanism in hypertrophic cardiomyopathy.Heart (British Cardiac Society) · 2020Article
- How Do PET Myocardial Blood Flow Reserve and FFR Differ?Current cardiology reports · 2020Review
- Coronary Microcirculation in Aortic Stenosis.Circulation. Cardiovascular interventions · 2019Review
- Hybrid cardiac imaging using PET/MRI: a joint position statement by the European Society of Cardiovascular Radiology (ESCR) and the European Association of Nuclear Medicine (EANM).European radiology · 2018Review
- Radionuclide imaging of subendocardial ischaemia: an insight into coronary pathophysiology or a technical artefact?European journal of nuclear medicine and molecular imaging · 2017Article
- Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM).European journal of nuclear medicine and molecular imaging · 2016Review
- New frontiers for cardiac PET: looking beyond mean transmural myocardial quantification.European journal of nuclear medicine and molecular imaging · 2015Article
- Validation of pixel-wise parametric mapping of myocardial blood flow with ¹³NH₃ PET in patients with hypertrophic cardiomyopathy.European journal of nuclear medicine and molecular imaging · 2015Article
- The myocardial oxygen supply:demand index revisited.Journal of the American Heart Association · 2014Review
- PET tracers and techniques for measuring myocardial blood flow in patients with coronary artery disease.Journal of biomedical research · 2013Review
- Quantitative myocardial perfusion imaging by cardiovascular magnetic resonance and positron emission tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPositron emission tomography (PET) enables robust and reproducible measurements of myocardial blood flow (MBF). However, the relatively limited resolution of PET till recently prohibited distinction between the subendocardial and the subepicardial layers in non-hypertrophied myocardium. Recent developments in hard- and software, however, have enabled to identify a transmural gradient difference in animal experiments. The aim of this study is to determine the feasibility of subendocardial and subepicardial MBF in normal human hearts assessed with (15)O-labeled water PET.
methodsTwenty-seven healthy subjects (mean age 41 ± 13 years; 11 men) were studied with (15)O-labeled water PET to quantify resting and hyperaemic (adenosine) MBF at a subendocardial and subepicardial level. In addition, cardiac magnetic resonance imaging was performed to determine left ventricular (LV) volumes and function.
resultsMean rest MBF was 1.46 ± 0.49 in the subendocardium, and 1.14 ± 0.342 mL · min(-1) · g(-1) in the subepicardium (P < .001). MBF during vasodilation was augmented to a greater extent at the subepicardial level (subendocardium vs subepicardium: 3.88 ± 0.86 vs 4.14 ± 0.88 mL · min(-1) · g(-1), P = .013). The endocardial-to-epicardial MBF ratio decreased significantly during hyperaemia (1.35 ± 0.23 to 1.12 ± 0.20, P < .001). Hyperaemic transmural MBF was inversely correlated with left ventricular end-diastolic volume index (LVEDVI) (r (2) = 0.41, P = .0003), with greater impact however at the subendocardial level.
conclusions(15)O-labeled water PET enables MBF measurements with distinction of the subendocardial and subepicardial layers in the normal human heart and correlates with LVEDVI. This PET technique may prove useful in evaluating patients with signs of ischaemia due to coronary artery disease or microvascular dysfunction.
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