ReviewMolecular and cellular biochemistry2011
Regulation of melanocyte pivotal transcription factor MITF by some other transcription factors.
Review in Molecular and cellular biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 106 citations in OpenAlex.
- Enhancement of Anti-Melanogenic Activity ofMarine drugs · 2026Article
- Integrating landscape genomics and machine learning to analyze the genetic structure and specific molecular markers of Chinese dairy goats (Capra hircus).Journal of animal science and biotechnology · 2026Article
- MITF Is an Essential and Functionally Multifaceted Transcription Factor in Cutaneous Melanoma.Cancers · 2026Review
- The influence of different regulatory patterns of miRNA-target genes on the pigmentation of the Chinese soft-shelled turtle (Pelodiscus sinensis).Scientific reports · 2026Article
- Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation.International journal of molecular sciences · 2026Review
- Whole-genome sequencing reveals complex structural variations at a major locus linked to pigmented spot sizes in Tianfu goats.BMC genomics · 2025Article
- Effect of dual optical pulse scheme with supra and subthreshold fluences on laser micro ablation of pigment.Scientific reports · 2025Article
- Pentagalloylglucose Inhibits Melanogenesis via Suppression of MITF Signaling Pathway.International journal of molecular sciences · 2025Article
- HSV-1 inhibits melanogenesis of PIG1 cells through downregulation of VN1R5/ERK pathway.Archives of dermatological research · 2025Article
- cAMP-Mediated CREM-MITF-TYR Axis Regulates Melanin Synthesis in Pacific Oysters.Marine biotechnology (New York, N.Y.) · 2024Article
- Human Mesenchymal Stem Cell-Derived Exosomes Promote the Proliferation and Melanogenesis of Primary Melanocytes by Attenuating the HClinical, cosmetic and investigational dermatology · 2024Article
- Targeting phosphorylation circuits on CREB and CRTCs as the strategy to prevent acquired skin hyperpigmentation.International journal of biological sciences · 2024Article
- Interruption of p38International journal of biological sciences · 2024Article
- Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells.Purinergic signalling · 2023Article
- Article
- The Mechanisms of Fur Development and Color Formation in American Mink Revealed Using Comparative Transcriptomics.Animals : an open access journal from MDPI · 2022Article
- Genome-wide association analysis reveal the genetic reasons affect melanin spot accumulation in beak skin of ducks.BMC genomics · 2022Article
- Fraxinol Stimulates Melanogenesis in B16F10 Mouse Melanoma Cells through CREB/MITF Signaling.Molecules (Basel, Switzerland) · 2022Article
- New insights into the prognosis of intraocular malignancy: Interventions for association mechanisms between cancer and diabetes.Frontiers in oncology · 2022Review
- Monodactylous Longitudinal Melanonychia: A Sign of Bowen's Disease in Skin of Color.Skin appendage disorders · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microphthalmia transcription factor (MITF) is discussed as the master gene for melanocytic survival and a key transcription factor regulating the expression of tyrosinase (TYR), tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2). MITF is influenced in a complex manner by a large number of different extracellular and intracellular proteins. Many transcription factors are able to modulate the expression and/or transcriptional activity of MITF in vivo. In this review, we summarize these transcription factors that regulate MITF and their interactions. The Sry-related HMG box 10 (SOX10) can directly transactivate the MITF gene and cooperate with MITF to activate TRP-2 expression. The Paired box 3 (PAX3) can increase MITF expression by binding to its promoter and simultaneously prevent MITF from activating downstream genes by competition for enhancer occupancy. Activated signal transducer and activator of transcription 3 (STAT3) and protein inhibitor of activated STAT3 (PIAS3) are able to regulate transcriptional activity of MITF through their interaction. Activated cAMP response element binding protein (CREB) can bind the cAMP response element to increase the MITF gene expression. MITF expression can also be initiated by lymphoid-enhancing factor-1 (LEF-1) and be temporally facilitated by the synergy of LEF-1 and MITF. Both immunoglobulin transcription factor-2 (ITF2) and forkhead-box transcription factor D3 (FOXD3) can negatively regulate MITF expression. All the above-mentioned transcription factors constitute a regulatory network that precisely modulates the MITF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.