ReviewMolecular genetics and genomics : MGG2011
Identification of molecular genetic factors that influence migraine.
Review in Molecular genetics and genomics : MGG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1 citations in OpenAlex.
- Association between migraine and epilepsy: a meta-analysis.Frontiers in neurology · 2023Pooled it
- Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.PloS one · 2015Pooled it
- Effects of tumor necrosis factor-β (TNF-β) 252A>G polymorphism on the development of migraine: a meta-analysis.PloS one · 2014Pooled it
- Migraine is a dysfunction of neuronal potassium ion channels.Frontiers in neurology · 2025Review
- Response Surface Optimization, Fabrication andPharmaceutical nanotechnology · 2025Article
- Advances in genetics of migraine.The journal of headache and pain · 2019Review
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.Journal of affective disorders · 2015Article
- Association of endothelial nitric oxide synthase gene polymorphisms (894G/T, -786T/C, G10T) and clinical findings in patients with migraine.Neuromolecular medicine · 2014Article
- Ion channels and migraine.Headache · 2014Review
- Studies on the pathophysiology and genetic basis of migraine.Current genomics · 2013Article
- Genes and primary headaches: discovering new potential therapeutic targets.The journal of headache and pain · 2013Review
- Lack of association between the MTHFR C677T variant and migraine with aura in an older population: could selective survival play a role?Cephalalgia : an international journal of headache · 2013Article
- Interaction among nitric oxide (NO)-related genes in migraine susceptibility.Molecular and cellular biochemistry · 2012Article
- Future possibilities in migraine genetics.The journal of headache and pain · 2012Review
- Migraine headache: a review of the molecular genetics of a common disorder.The journal of headache and pain · 2012Review
- Haplotypes in candidate genes related to nitric oxide pathway and vascular permeability associated with migraine and aura.The journal of headache and pain · 2012Article
- Headaches of otolaryngological interest: current status while awaiting revision of classification. Practical considerations and expectations.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2012Review
- Functional analysis of missense variants in the TRESK (KCNK18) K channel.Scientific reports · 2012Article
- Preventive agents for migraine: focus on the antiepileptic drugs.Journal of central nervous system disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a common neurological disorder with a strong genetic basis. However, the complex nature of the disorder has meant that few genes or susceptibility loci have been identified and replicated consistently to confirm their involvement in migraine. Approaches to genetic studies of the disorder have included analysis of the rare migraine subtype, familial hemiplegic migraine with several causal genes identified for this severe subtype. However, the exact genetic contributors to the more common migraine subtypes are still to be deciphered. Genome-wide studies such as genome-wide association studies and linkage analysis as well as candidate genes studies have been employed to investigate genes involved in common migraine. Neurological, hormonal and vascular genes are all considered key factors in the pathophysiology of migraine and are a focus of many of these studies. It is clear that the influence of individual genes on the expression of this disorder will vary. Furthermore, the disorder may be dependent on gene--gene and gene--environment interactions that have not yet been considered. In addition, identifying susceptibility genes may require phenotyping methods outside of the International Classification of Headache Disorders II criteria, such as trait component analysis and latent class analysis to better define the ambit of migraine expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.