ArticleThe Journal of membrane biology2011
Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family.
Article in The Journal of membrane biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Zebrafish Tric-b is required for skeletal development and bone cells differentiation.Frontiers in endocrinology · 2023Article
- Origins of eukaryotic excitability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- TRIC-A regulates intracellular CaPflugers Archiv : European journal of physiology · 2021Review
- Functional Innovation in the Evolution of the Calcium-Dependent System of the Eukaryotic Endoplasmic Reticulum.Frontiers in genetics · 2020Article
- Structural basis for activity of TRIC counter-ion channels in calcium release.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Structural basis for conductance through TRIC cation channels.Nature communications · 2017Article
- Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel.BMC biology · 2017Article
- Crystal structures of the TRIC trimeric intracellular cation channel orthologues.Cell research · 2016Article
- Comparative analyses of transport proteins encoded within the genomes of Leptospira species.Microbial pathogenesis · 2016Article
- Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species.Microbial pathogenesis · 2015Article
- Reliability of nine programs of topological predictions and their application to integral membrane channel and carrier proteins.Journal of molecular microbiology and biotechnology · 2014Article
- The transporter classification database.Nucleic acids research · 2014Article
- TRIC channels supporting efficient Ca(2+) release from intracellular stores.Pflugers Archiv : European journal of physiology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Trimeric intracellular cation-specific (TRIC) channels are integral to muscle excitation-contraction coupling. TRIC channels provide counter-ionic flux when calcium is rapidly transported from intracellular stores to the cell cytoplasm. Until recently, knowledge of the presence of these proteins was limited to animals. We analyzed the TRIC family and identified a profusion of prokaryotic family members with topologies and motifs similar to those of their eukaryotic counterparts. Prokaryotic members far outnumber eukaryotic members, and although none has been functionally characterized, the evidence suggests that they function as secondary carriers. The presence of fused N- or C-terminal domains of known biochemical functions as well as genomic context analyses provide clues about the functions of these prokaryotic homologs. They are proposed to function in metabolite (e.g., amino acid/nucleotide) efflux. Phylogenetic analysis revealed that TRIC channel homologs diverged relatively early during evolutionary history and that horizontal gene transfer was frequent in prokaryotes but not in eukaryotes. Topological analyses of TRIC channels revealed that these proteins possess seven putative transmembrane segments (TMSs), which arose by intragenic duplication of a three-TMS polypeptide-encoding genetic element followed by addition of a seventh TMS at the C terminus to give the precursor of all current TRIC family homologs. We propose that this family arose in prokaryotes.
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Registered trials
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