ArticleInternational journal of colorectal disease2011
Electrogenic transport, oxygen consumption, and sensitivity to acute hypoxia of human colonic epithelium.
Article in International journal of colorectal disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Intestinal oxygen and microbiota crosstalk: implications for pathogenesis of gastrointestinal diseases and emerging therapeutic strategies.Gut pathogens · 2025Review
- Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes.npj metabolic health and disease · 2025Review
- Physiologic hypoxia in the intestinal mucosa: a central role for short-chain fatty acids.American journal of physiology. Cell physiology · 2024Review
- Revisiting the "starved gut" hypothesis in inflammatory bowel disease.Immunometabolism (Cobham, Surrey) · 2023Review
- Butyrate Protects Porcine Colon Epithelium from Hypoxia-Induced Damage on a Functional Level.Nutrients · 2021Article
- Hypoxia attenuate ionic transport in the isolated gill epithelium of Carcinus maenas.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- An in vitro intestinal platform with a self-sustaining oxygen gradient to study the human gut/microbiome interface.Biofabrication · 2019Article
- Rectification of oxygen transfer through the rat colonic epithelium.World journal of gastrointestinal pathophysiology · 2017Article
- Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia.American journal of physiology. Cell physiology · 2015Review
- Oxygen in the regulation of intestinal epithelial transport.The Journal of physiology · 2014Review
- The effect of acute hypoxia on short-circuit current and epithelial resistivity in biopsies from human colon.Digestive diseases and sciences · 2013Article
- The effects of amiloride and age on oxygen consumption coupled to electrogenic sodium transport in the human sigmoid colon.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIt is recognized that epithelial ion transport depends on oxygen supply, but this dependence has not been characterized in the human colon in vitro despite its surgical and clinical implications. PURPOSES: The aim of this study is to measure the oxygen consumption of colonic epithelium under conditions which preserve vectorial ion transport and to assess the sensitivity of the human colonic epithelium short-circuit current (I (sc)) to acute hypoxia induced in vitro.
methodsIsolated mucosa preparations from human sigmoid colon were placed in a modified Ussing chamber which allows simultaneous measurement of short-circuit current (I (sc)) and oxygen consumption (QO(2)). In separate experiments, the sensitivity to acute hypoxia induced in a conventional Ussing chamber was assessed.
resultsBasal mean ± SEM values (n = 8) were I (sc) = 3.3 ± 0.5 μEq h(-1) cm(-2) and QO(2) = 8.09 ± 0.55 μmol h(-1) cm(-2). The contribution of the serosal side to the oxygen supply was higher than that of the mucosal side (p = 0.0023). Ouabain reduced I (sc) by 70% (P < 0.0001) and QO(2) by 26% (n = 8; P = 0.0009), suggesting that a large fraction of QO(2) is needed to support ouabain-sensitive electrogenic transport. Induction of hypoxia at both sides of the Ussing chamber caused a rapid decrease in I (sc) after 2 min. I (sc) was also significantly depressed when hypoxia was induced by 5 min in the serosal side (n = 6, P < 0.0001), but was unaffected by hypoxia induced in the mucosal side.
conclusionThe present results allow a better understanding of the clinical consequences of acute hypoxia on intestinal ion transport.
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