ArticleJournal of Korean Neurosurgical Society2011
The effect of minocycline on motor neuron recovery and neuropathic pain in a rat model of spinal cord injury.
Article in Journal of Korean Neurosurgical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Insights into the roles of bacterial infection and antibiotics in Parkinson's disease.Frontiers in cellular and infection microbiology · 2022Review
- Tetracycline repurposing in neurodegeneration: focus on Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Recent advances in the pharmacologic treatment of spinal cord injury.Metabolic brain disease · 2015Review
- Remote neurodegeneration: multiple actors for one play.Molecular neurobiology · 2014Review
- Article
- Opioid administration following spinal cord injury: implications for pain and locomotor recovery.Experimental neurology · 2013Review
- Minocycline: far beyond an antibiotic.British journal of pharmacology · 2013Review
- Separation Differences Among Phenyl Hydride, UDC Cholesterol and Bidentate C8 Stationary Phases for Stability Indicating Methods of Tetracyclines: Journal of Liquid Chromatography & Related Technologies.Journal of liquid chromatography & related technologies · 2013Article
- Prolonged minocycline treatment impairs motor neuronal survival and glial function in organotypic rat spinal cord cultures.PloS one · 2013Article
- The effect of minocycline on the masticatory movements following the inferior alveolar nerve transection in freely moving rats.Molecular pain · 2012Article
- The neuroprotective effect of treatment of valproic Acid in acute spinal cord injury.Journal of Korean Neurosurgical Society · 2012Article
- The gut-brain axis and beyond: Microbiome control of spinal cord injury pain in humans and rodents.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMinocycline, a second-generation tetracycline-class antibiotic, has been well established to exert a neuroprotective effect in animal models and neurodegenerative disease through the inhibition of microglia. Here, we investigated the effects of minocycline on motor recovery and neuropathic pain in a rat model of spinal cord injury.
methodsTo simulate spinal cord injury, the rats' spinal cords were hemisected at the 10th thoracic level (T10). Minocycline was injected intraperitoneally, and was administered 30 minutes prior surgery and every second postoperative day until sacrifice 28 days after surgery. Motor recovery was assessed via the Basso-Beattie-Bresnahan test. Mechanical hyperalgesia was measured throughout the 28-day post-operative course via the von Frey test. Microglial and astrocyte activation was assessed by immunohistochemical staining for ionized calcium binding adaptor molecule 1 (Iba1) and glial fibrillary acidic protein (GFAP) at two sites: at the level of hemisection and at the 5th lumbar level (L5).
resultsIn rats, spinal cord hemisection reduced locomotor function and induced a mechanical hyperalgesia of the ipsilateral hind limb. The expression of Iba1 and GFAP was also increased in the dorsal and ventral horns of the spinal cord at the site of hemisection and at the L5 level. Intraperitoneal injection of minocycline facilitated overall motor recovery and attenuated mechanical hyperalgesia. The expression of Iba1 and GFAP in the spinal cord was also reduced in rats treated with minocycline.
conclusionBy inhibiting microglia and astrocyte activation, minocycline may facilitate motor recovery and attenuate mechanical hyperalgesia in individuals with spinal cord injuries.
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