ReviewNature reviews. Cardiology2011
Heart rate: a forgotten link in coronary artery disease?
Review in Nature reviews. Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Predicting disease outcomes from remote monitoring using machine learning: a systematic review.BMC medical informatics and decision making · 2026Pooled it
- Effect of ivabradine-induced heart rate reduction on flow-mediated dilation measured with high-sensitivity ultrasound in patients with stable coronary heart disease.Cardiovascular ultrasound · 2014Trial
- Personalized management of angina and heart failure in clinical practice in the Middle East: a narrative review.Journal of comparative effectiveness research · 2026Review
- Adaptive physiology-informed correction for reliable remote photoplethysmography heart-rate monitoring.NPJ digital medicine · 2026Article
- Predictive Equation for Peak Heart Rate and First Ventilatory Threshold Heart Rate in Patients With Coronary Heart Disease.Cardiology research and practice · 2026Article
- Suboptimal heart rate control despite beta-blocker use in coronary artery disease: evidence from the Fasa PERSIAN cohort.BMC cardiovascular disorders · 2025Article
- Acute live firefighting effects on ventricular-arterial coupling and pulsatile afterload in middle-aged firefighters.Physiological reports · 2025Article
- Associations of ischemic heart disease with brain glymphatic MRI indices and risk of Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025Article
- Correlation of the triglyceride-glucose index and heart rate with 28-day all-cause mortality in severely ill patients: analysis of the MIMIC-IV database.Lipids in health and disease · 2024Article
- Investigating Genetic Overlap between Alzheimer's Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis.International journal of molecular sciences · 2024Article
- Ivabradine in Septic Shock: A Narrative Review.Journal of clinical medicine · 2024Review
- The association of coronary artery disease with heart rate at anaerobic threshold and respiratory compensatory point.Frontiers in cardiovascular medicine · 2024Article
- Determinants of double product: a cross-sectional study of urban residents in Japan.Environmental health and preventive medicine · 2023Article
- The Effect of Antipsychotics and Their Combinations with Other Psychotropic Drugs on Electrocardiogram Intervals Other Than QTc among Jordanian Adult Outpatients.Biomedicines · 2022Article
- Prediction of SYNTAX score II improvement by adding temporal heart rate changes between discharge and first outpatient visit in patients with acute myocardial infarction.BMC cardiovascular disorders · 2022Article
- Resting heart rate and risk of left and right heart failure in 0.5 million Chinese adults.Open heart · 2022Article
- Association between heart rate and cardiovascular death in patients with coronary heart disease: A NHANES-based cohort study.Clinical cardiology · 2022Article
- Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Effects of Algorithmic Music on the Cardiovascular Neural Control.Journal of personalized medicine · 2021Article
- Effect of heart rate on hospital mortality in critically ill patients may be modified by age: a retrospective observational study from large database.Aging clinical and experimental research · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A considerable body of evidence indicates that elevated resting heart rate is an independent, modifiable risk factor for cardiovascular events and mortality in patients with coronary artery disease. Elevated heart rate can produce adverse effects in several ways. Firstly, myocardial oxygen consumption is increased at high heart rates, but the time available for myocardial perfusion is reduced, increasing the likelihood of myocardial ischemia. Secondly, exposure of the large elastic arteries to cyclical stretch is increased at high heart rates. This effect can increase the rate at which components of the arterial wall deteriorate. Elastin fibers, which have an extremely slow rate of turnover in adult life, might be particularly vulnerable. Thirdly, elevated heart rate can predispose the myocardium to arrhythmias, and favor the development and progression of coronary atherosclerosis, by adversely affecting the balance between systolic and diastolic flow. Comparisons of the effects of the specific heart-rate-lowering drug ivabradine with those of β-blockers could help clarify the pathophysiological effects of elevated heart rate. Effective heart rate control among patients with coronary artery disease is uncommon in clinical practice, representing a missed therapeutic opportunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.