ArticleCell research2011
T-cell vaccination leads to suppression of intrapancreatic Th17 cells through Stat3-mediated RORγt inhibition in autoimmune diabetes.
Article in Cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- T helper 17 cells and interleukin-17 immunity in type 1 diabetes: From pathophysiology to targeted immunotherapies.World journal of diabetes · 2025Review
- STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia.Cell death and differentiation · 2020Article
- IL-17 in pancreatic disease: pathogenesis and pharmacotherapy.American journal of cancer research · 2020Review
- Prospects of the Use of Cell Therapy to Induce Immune Tolerance.Frontiers in immunology · 2020Review
- IL-17 and limits of success.Cellular immunology · 2019Review
- Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus.Stem cell research & therapy · 2017Article
- ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes.Endocrinology · 2015Article
- Th17 Cells in Type 1 Diabetes: Role in the Pathogenesis and Regulation by Gut Microbiome.Mediators of inflammation · 2015Review
- The mechanisms and applications of T cell vaccination for autoimmune diseases: a comprehensive review.Clinical reviews in allergy & immunology · 2014Review
- Advances in the cellular immunological pathogenesis of type 1 diabetes.Journal of cellular and molecular medicine · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunization with inactivated autoreactive T cells is an effective therapeutic approach to ameliorating autoimmune diseases, while the underlying mechanisms that regulate autoreactive T cells are not completely understood. This study tested the hypothesis that T-cell vaccination (TCV) inhibits autoimmune diabetes in mice through the suppression of Th17 cells. The results showed that TCV treatment decreased hyperglycemia in type 1 diabetes (T1D) induced by multiple low-dose streptozotocin (MLD-STZ) as compared with the controls, preserved the number of healthy pancreatic islets and increased the production of insulin in the islets. Further study revealed that TCV significantly decreased the production of both interleukin (IL)-17 and IL-23 in intrapancreatic infiltrating lymphocytes (IPL) through marked inhibition of mRNA level of retinoic acid-related orphan receptor γt (RORγt) and signal transducer and activator of transcription 3 (Stat3) phosphorylation. The role of TCV-induced Th17 suppression was further validated in adoptive transfer experiments with polarized Th17 cells in sub-diabetogenic mice, which was similar to the effect of anti-IL-17 antibody treatment. Collectively our study shows that intrapancreatic Th17 cell suppression and healthy islet preservation play an important role in the treatment of T1D by TCV.
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