Evidence map›Paper›PMID 21519311›Full record

Trial reportRegional anesthesia and pain medicine

Ultrasound-guided (needle-in-plane) perineural catheter insertion: the effect of catheter-insertion distance on postoperative analgesia.

Brian M Ilfeld, Navparkash S Sandhu, Vanessa J Loland, Sarah J Madison, Preetham J Suresh, Edward R Mariano, Michael L Bishop, Alexandra K Schwartz, Daniel K Lee

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Regional anesthesia and pain medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02200016 (Displacement of Popliteal Sciatic Nerve Catheters After Major Foot and Ankle Surgery), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02200016 phase4completednot on this map

Displacement of Popliteal Sciatic Nerve Catheters After Major Foot and Ankle Surgery

TypeinterventionalSponsorKolding SygehusRan2014 to 2015Enrolled40ConditionsPostoperative Pain, Regional AnesthesiaArmsUltrasound guided short axis (SAX) placement of sciatic nerve catheters, Ultrasound guided long axis (LAX) placement of sciatic nerve catheters, B Braun Contiplex S catheter
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 33 citations in OpenAlex.

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  8. Double-tunneled catheter method for continuous peripheral nerve block.Journal of anaesthesiology, clinical pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Brian M IlfeldDepartment of Anesthesiology, University of California, San Diego, CA, USA. bilfeld@ucsd.edu
Navparkash S Sandhu
Vanessa J Loland
Sarah J Madison
Preetham J Suresh
Edward R Mariano
Michael L Bishop
Alexandra K Schwartz
Daniel K Lee
University of California, San Diego · US

Funding

Perineural Anesthetic Infusion After Joint ReplacementK23GM077026 · NIGMS · UNIVERSITY OF FLORIDA · PI ILFELD, BRIAN M · 2005 to 2009
$617k
NIGMS NIH HHS GM077026NIGMS NIH HHS K23 GM077026
6 · The paper itself

Abstract

backgroundWhen using ultrasound guidance to place a perineural catheter for a continuous peripheral nerve block, keeping the needle in plane and nerve in short axis results in a perpendicular needle-to-nerve orientation. Many have opined that when placing a perineural catheter via the needle, the acute angle may result in the catheter bypassing the target nerve when advanced beyond the needle tip. Theoretically, greater catheter tip-to-nerve distances result in less local anesthetic-to-nerve contact during the subsequent perineural infusion, leading to inferior analgesia. Although a potential solution may appear obvious-advancing the catheter tip only to the tip of the needle, leaving the catheter tip at the target nerve-this technique has not been prospectively evaluated. We therefore hypothesized that during needle in-plane ultrasound-guided perineural catheter placement, inserting the catheter a minimum distance (0-1 cm) past the needle tip is associated with improved postoperative analgesia compared with inserting the catheter a more traditional 5 to 6 cm past the needle tip.

methodsPreoperatively, subjects received a popliteal-sciatic perineural catheter for foot or ankle surgery using ultrasound guidance exclusively. Subjects were randomly assigned to have a single-orifice, flexible catheter inserted either 0 to 1 cm (n = 50) or 5 to 6 cm (n = 50) past the needle tip. All subjects received a single-injection mepivacaine (40 mL of 1.5% with epinephrine) nerve block via the needle, followed by catheter insertion and a ropivacaine 0.2% infusion (basal 6 mL/hr, bolus 4 mL, 30-min lockout), through at least the day after surgery. The primary end point was the average surgical pain as measured with a 0- to 10-point numeric rating scale the day after surgery. Secondary end points included time for catheter insertion, incidence of catheter dislodgement, maximum ("worst") pain scores, opioid requirements, fluid leakage at the catheter site, and the subjective degree of an insensate extremity.

resultsAverage pain scores the day after surgery for subjects of the 0- to 1-cm group were a median of 2.5 (interquartile range, 0.0-5.0), compared with 2.0 (interquartile range, 0.0-4.0) for subjects of the 5- to 6-cm group (P = 0.42). Similarly, among the secondary end points, no statistically significant differences were found between the 2 treatment groups. There was a trend of more catheter dislodgements in the minimum-insertion group (5 vs 1; P = 0.20).

conclusionsThis study did not find evidence to support the hypothesis that, for popliteal-sciatic perineural catheters placed using ultrasound guidance and a needle-in-plane technique, inserting the catheter a minimum distance (0-1 cm) past the needle tip improves (or worsens) postoperative analgesia compared with inserting the catheter a more traditional distance (5-6 cm). Caution is warranted if extrapolating these results to other catheter designs, ultrasound approaches, or anatomic insertion sites.

Indexed as

NeedlesAdultAnesthetics, LocalAutonomic Nerve BlockCatheterizationFemaleHumansMaleMiddle AgedPeroneal NervePostoperative PainProspective StudiesSciatic NerveUltrasonography, InterventionalAnesthetics, Local

Identifiers

PMID21519311
PMCPMC3085850
OpenAlexW2323368414

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.