Trial reportJournal of pediatric gastroenterology and nutrition2011
Individually tailored treatment of medication nonadherence.
Trial report in Journal of pediatric gastroenterology and nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Interventions for improving treatment adherence in young people with inflammatory bowel disease (IBD): A systematic review of behaviour change theory and behaviour change techniques.Journal of child health care : for professionals working with children in the hospital and community · 2026Pooled it
- Psychological interventions for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2025Pooled it
- Interventions to Promote Oral Medication Adherence in the Pediatric Chronic Illness Population: A Systematic Review From the Children's Oncology Group.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesPooled it
- A pilot randomized controlled trial of the self-management assistance for recommended treatment inflammatory bowel disease app for adolescents with inflammatory bowel disease.Journal of pediatric gastroenterology and nutrition · 2026Trial
- Trial
- The Telehealth Enhancement of Adherence to Medication (TEAM) in pediatric IBD trial: Design and methodology.Contemporary clinical trials · 2015Trial
- Preliminary feasibility, acceptability, and efficacy of an innovative adherence intervention for children with newly diagnosed epilepsy.Journal of pediatric psychology · 2013Trial
- Telehealth behavioral treatment for medication nonadherence: a pilot and feasibility study.European journal of gastroenterology & hepatology · 2013Trial
- Self-Management assistance for recommended treatment (SMART) IBD app randomized control trial in adolescents with IBD: Design and methodology.Health care transitions · 2024Article
- Barriers to medication adherence among adolescents and young adults with cancer.Pediatric blood & cancer · 2023Observational
- Digital Therapeutic Self-Management Intervention in Adolescents With Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2023Article
- Leveraging Institutional Support to Build an Integrated Multidisciplinary Care Model in Pediatric Inflammatory Bowel Disease.Children (Basel, Switzerland) · 2021Article
- Initial Validation of IBD KNOW-IT: Measuring Patient and Caregiver Knowledge of a Child's Disease and Treatment Regimen.Journal of clinical psychology in medical settings · 2020Article
- Body Image, Emotional Eating and Psychological Distress among Bariatric Surgery Candidates in Israel and the United States.Nutrients · 2020Article
- Adherence in pediatric kidney transplant recipients: solutions for the system.Pediatric nephrology (Berlin, Germany) · 2018Review
- Practice survey: adherence monitoring and intervention in pediatric gastroenterology and hepatology.Therapeutics and clinical risk management · 2018Article
- Medication adherence in inflammatory bowel disease.Intestinal research · 2017Review
- Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseases.Clinical and translational gastroenterology · 2017Article
- Impact of patient programs on adherence and persistence in inflammatory and immunologic diseases: a meta-analysis.Patient preference and adherence · 2015Article
- Web-based interventions for ulcerative colitis and Crohn's disease: systematic review and future directions.Clinical and experimental gastroenterology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveNonadherence is a significant health care issue in pediatric inflammatory bowel disease (IBD) that requires intervention to improve outcomes. This pilot randomized controlled trial was designed to evaluate the feasibility, acceptability, and preliminary efficacy of an individually tailored behavioral treatment for nonadherence in adolescents with IBD. PATIENTS AND
methodsFourteen adolescents ages 14.89 ± 2.01 years were randomly assigned to immediate care or wait list control conditions and received a manualized individually tailored behavioral intervention for nonadherence. Medication adherence, measured by pill count, served as the primary endpoint. Parents provided demographic data and ratings of intervention acceptability and patients provided disease-severity data.
resultsFeasibility of the treatment was demonstrated by 100% treatment session attendance for all of the patients enrolled in the trial. Both parent and patient acceptability ratings were favorable. Comparison of baseline with posttreatment percent adherence across both conditions demonstrated that treatment resulted in a 4% gain in 6-mercaptopurine/azathioprine adherence (52% at baseline; 56% at posttreatment; δ = 0.07) and a 25% gain in mesalamine adherence (43% at baseline; 68% at posttreatment; δ = 0.57).
conclusionsIndividually tailored treatment of nonadherence in adolescents with IBD is feasible and may result in substantial improvement in medication adherence. Differential effect of the intervention on medications requires further investigation, but it may reflect differences in regimen complexity, concerns about medication adverse effects, and/or patient/parent preference to target more complex regimens. Large-scale testing of this intervention is needed to demonstrate effect on clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.