Evidence map›Paper›PMID 21519246›Full record

ReviewCurrent opinion in HIV and AIDS2011

Renal disease in HIV-infected individuals.

John Phair, Frank Palella

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current opinion in HIV and AIDS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01869010 (Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01869010 completednot on this map

Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2010 to 2012Enrolled30ConditionsHIV InfectionArmsLow sodium water overload in HIV tenofovir, HIV no tenofovir and seronegative controls
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
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  11. Observational
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  20. Prehypertension, hypertension, and the risk of acute myocardial infarction in HIV-infected and -uninfected veterans.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John PhairFeinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. j-phair@northwestern.edu
Frank Palella
Northwestern University · US

Funding

MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
The Aging Kidney in HIV-Infection: biomarkers for early detection of injuryR01AG034853 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ESTRELLA, MICHELLE M, SHLIPAK, MICHAEL G · 2010 to 2025
$9.6M
Subclinical Vascular Disease and Metabolic Abnormalities in MACSR01HL095129 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2008 to 2012
$4.9M
DEVELOPMENTAL CONTROL OF IL-2 TRANSCRIPTION FACTORSR01AI034041 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROTHENBERG, ELLEN V. · 1993 to 1997
–
NHLBI NIH HHS 1R01HL095129NHLBI NIH HHS R01 HL095129NIAID NIH HHS U01AI034041NIAID NIH HHS U01 AI035039NIA NIH HHS 1520// R01AG034853NIA NIH HHS R01AG0348522NIA NIH HHS R01 AG034853PHS HHS 200-2006-18797PHS HHS U01AIO35039
6 · The paper itself

Abstract

purpose of reviewHighly active antiretroviral therapy (HAART) has resulted in a marked decrease in AIDS-related conditions and death. With improved survival, cardiovascular disease, hepatic, renal disease, and non-AIDS-related cancers represent an increasing burden for HIV-infected individuals. RECENT

findingsHIV-associated nephropathy (HIVAN), acute renal injury, HAART, and comorbid conditions such as hepatitis C, hypertension, and diabetes are among the multiple causes of renal disease. In HIVAN there is incomplete understanding of the interaction of the virus with renal cells and the host genetics leading to susceptibility to this form of renal dysfunction. There is agreement that a baseline estimated glomerular filtration should be obtained and that renal function should be monitored during antiretroviral therapy. There is, however, no agreement as to the most accurate method of estimating GFR. Renal transplantation has emerged as a feasible and successful modality of management of end-stage renal disease (ESRD) in HIV-infected individuals. SUMMARY: Kidney disease represents an increasing concern in the care of HIV-infected persons, although there are questions remaining regarding the pathophysiology of HIVAN. Transplantation, however, can be carried out safely in infected persons with ESRD.

Indexed as

AIDS-Associated NephropathyAnti-HIV AgentsHepatitis CHIV InfectionsHumansIncidenceAnti-HIV Agents

Identifiers

PMID21519246
PMCPMC3266688
OpenAlexW2043847276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.