ReviewOrganogenesis
Selecting the optimal cell for kidney regeneration: fetal, adult or reprogrammed stem cells.
Review in Organogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Urine-derived stem cells display homing, incorporation, and regeneration in human organoid and mouse models of acute kidney injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- OCT4 induces long-lived dedifferentiated kidney progenitors poised to redifferentiate in 3D kidney spheroids.Molecular therapy. Methods & clinical development · 2023Article
- Successful Introduction of Human Renovascular Units into the Mammalian Kidney.Journal of the American Society of Nephrology : JASN · 2020Article
- Renal lineage cells as a source for renal regeneration.Pediatric research · 2018Review
- Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level.Stem cell reports · 2017Article
- Peroxisome proliferator-activated receptor gamma (PPARγ) is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic targetEMBO molecular medicine · 2017Article
- Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells.Scientific reports · 2016Article
- Immature Dental Pulp Stem Cells Showed Renotropic and Pericyte-Like Properties in Acute Renal Failure in Rats.Cell medicine · 2015Article
- Fetal kidney stem cells ameliorate cisplatin induced acute renal failure and promote renal angiogenesis.World journal of stem cells · 2015Article
- The lymph node as a new site for kidney organogenesis.Stem cells translational medicine · 2015Article
- Engineering kidneys from simple cell suspensions: an exercise in self-organization.Pediatric nephrology (Berlin, Germany) · 2014Review
- Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system.PloS one · 2014Article
- Restitutio ad integrum: a dream or a real possibility?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2013Article
- Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease.EMBO molecular medicine · 2013Article
- Epoxyeicosanoids promote organ and tissue regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Chromatin-modifying agents reactivate embryonic renal stem/progenitor genes in human adult kidney epithelial cells but abrogate dedifferentiation and stemness.Cellular reprogramming · 2013Article
- Illustration of extensive extracellular matrix at the epithelial-mesenchymal interface within the renal stem/progenitor cell niche.BMC clinical pathology · 2012Article
- Detrimental effects of rat mesenchymal stromal cell pre-treatment in a model of acute kidney rejection.Frontiers in immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease (CKD) is a progressive loss in renal function over a period of months or years. End-stage renal disease (ESRD) or stage 5 CKD ensues when renal function deteriorates to under 15% of the normal range. ESRD requires either dialysis or, preferentially, a kidney organ allograft, which is severely limited due to organ shortage for transplantation. To combat this situation, one needs to either increase supply of organs or decrease their demand. Two strategies therefore exist: for those that have completely lost their kidney function (ESRD), we will need to supply new kidneys. Taking into account the kidneys' extremely complex structure, this may prove to be impossible in the near future. In contrast, for those patients that are in the slow progression route from CKD to ESRD but still have functional kidneys, we might be able to halt progression by introducing stem cell therapy to diseased kidneys to rejuvenate or regenerate individual cell types. Multiple cell compartments that fall into three categories are likely to be worthy targets for cell repair: vessels, stroma (interstitium) and nephron epithelia. Different stem/progenitor cells can be linked to regeneration of specific cell types; hematopoietic progenitors and hemangioblastic cell types have specific effects on the vascular niche (vasculogenesis and angiogenesis). Multipotent stromal cells (MSC), whether derived from the bone marrow or isolated from the kidney's non-tubular compartment, may, in turn, heal nephron epithelia via paracrine mechanisms. Nevertheless, as we now know that all of the above lack nephrogenic potential, we should continue our quest to derive genuine nephron (epithelial) progenitors from differentiated pluripotent stem cells, from fetal and adult kidneys and from directly reprogrammed somatic cells.
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