Evidence map›Paper›PMID 21519147›Full record

ArticleThe Journal of clinical investigation2011

Fibulin-5: two for the price of one maintaining pelvic support.

Gina M Northington

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Collagen organization and structure inBiomedical optics express · 2024
    Article
  4. Collagen organization and structure inbioRxiv : the preprint server for biology · 2024
    Article
  5. Review
  6. Advances in molecular mechanisms of pelvic organ prolapse (Review).Experimental and therapeutic medicine · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Gina M NorthingtonDepartment of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.  gnorthington@obgyn.upenn.edu
University of Pennsylvania · US

Funding

NICHD NIH HHS K12-HD00165-11
6 · The paper itself

Abstract

Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is a complex problem that likely involves multiple mechanisms, and available therapies are limited. In this issue of the JCI, Budatha et al. explore the dual role carried out by fibulin-5 in facilitating the assembly of normal elastic fibers and inhibiting MMP-9 activity, revealing a new mechanism critical to the maintenance of pelvic organ support.

Indexed as

AnimalsDisease Models, AnimalElastic TissueElastinExtracellular Matrix ProteinsFemaleHumansMatrix Metalloproteinase 9MiceMice, TransgenicPelvic FloorPelvic Organ ProlapseProtein Structure, TertiaryTropoelastinVaginaElastinExtracellular Matrix ProteinsFBLN5 protein, humanMatrix Metalloproteinase 9Tropoelastin

Identifiers

PMID21519147
PMCPMC3083791
OpenAlexW1989833063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.