ArticleProceedings of the National Academy of Sciences of the United States of America2011
Structural mechanism of the ATP-induced dissociation of rigor myosin from actin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Chemically-fueled phase transition of a redox-responsive polymer.Science and technology of advanced materials · 2025Article
- Fabrication of Self-Oscillating Gels by Polymer Crosslinking Method and Analysis on Their Autonomous Swelling-Deswelling Behaviors.Gels (Basel, Switzerland) · 2022Article
- Actomyosin Complex.Sub-cellular biochemistry · 2022Article
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- Decrease in membrane fluidity and traction force induced by silica-coated magnetic nanoparticles.Journal of nanobiotechnology · 2021Article
- ATP Analogues for Structural Investigations: Case Studies of a DnaB Helicase and an ABC Transporter.Molecules (Basel, Switzerland) · 2020Review
- Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.Skeletal muscle · 2020Article
- Overview of the mechanism of cytoskeletal motors based on structure.Biophysical reviews · 2018Review
- Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil.PLoS computational biology · 2017Article
- Structural model of weak binding actomyosin in the prepowerstroke state.The Journal of biological chemistry · 2015Article
- Catalytic strategy used by the myosin motor to hydrolyze ATP.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Stabilization of the ADP/metaphosphate intermediate during ATP hydrolysis in pre-power stroke myosin: quantitative anatomy of an enzyme.The Journal of biological chemistry · 2013Article
- Capture and quality control mechanisms for adenosine-5'-triphosphate binding.Journal of the American Chemical Society · 2013Article
- Conformationally trapping the actin-binding cleft of myosin with a bifunctional spin label.The Journal of biological chemistry · 2013Article
- Switch II mutants reveal coupling between the nucleotide- and actin-binding regions in myosin V.Biophysical journal · 2012Article
- How myosin motors power cellular functions: an exciting journey from structure to function: based on a lecture delivered at the 34th FEBS Congress in Prague, Czech Republic, July 2009.The FEBS journal · 2012Article
- Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulations.PLoS computational biology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myosin is a true nanomachine, which produces mechanical force from ATP hydrolysis by cyclically interacting with actin filaments in a four-step cycle. The principle underlying each step is that structural changes in separate regions of the protein must be mechanically coupled. The step in which myosin dissociates from tightly bound actin (the rigor state) is triggered by the 30 Å distant binding of ATP. Large conformational differences between the crystal structures make it difficult to perceive the coupling mechanism. Energetically accessible transition pathways computed at atomic detail reveal a simple coupling mechanism for the reciprocal binding of ATP and actin.
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