ArticleProceedings of the National Academy of Sciences of the United States of America2011
Identification of key factors that reduce the variability of the single photon response.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of cell size and bicarbonate on single photon response variability in retinal rods.Frontiers in molecular neuroscience · 2022Article
- Pepperberg plot: Modeling flash response saturation in retinal rods of mouse.Frontiers in molecular neuroscience · 2022Article
- Analysis of waveform and amplitude of mouse rod and cone flash responses.The Journal of physiology · 2021Article
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- Article
- Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods.PloS one · 2019Article
- Temporal resolution of single-photon responses in primate rod photoreceptors and limits imposed by cellular noise.Journal of neurophysiology · 2019Article
- Sperm Sensory Signaling.Cold Spring Harbor perspectives in biology · 2017Review
- How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- The phototransduction machinery in the rod outer segment has a strong efficacy gradient.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses.Frontiers in molecular neuroscience · 2015Review
- High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor.The Journal of cell biology · 2014Article
- Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling.Cell communication and signaling : CCS · 2013Article
- Engineering visual arrestin-1 with special functional characteristics.The Journal of biological chemistry · 2013Article
- Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes.Neuron · 2012Article
- Spatiotemporal cGMP dynamics in living mouse rods.Biophysical journal · 2012Article
- G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.Pharmacology & therapeutics · 2012Review
- The functional cycle of visual arrestins in photoreceptor cells.Progress in retinal and eye research · 2011Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Rod photoreceptors mediate vision in dim light. Their biological function is to discriminate between distinct, very low levels of illumination, i.e., they serve as reliable photon counters. This role requires high reproducibility of the response to a particular number of photons. Indeed, single photon responses demonstrate unexpected low variability, despite the stochastic nature of the individual steps in the transduction cascade. We analyzed individual system mechanisms to identify their contribution to variability suppression. These include: (i) cooperativity of the regulation of the second messengers; (ii) diffusion of cGMP and Ca(2+) in the cytoplasm; and (iii) the effect of highly localized cGMP hydrolysis by activated phosphodiesterase resulting in local saturation. We find that (i) the nonlinear relationships between second messengers and current at the plasma membrane, and the cGMP hydrolysis saturation effects, play a major role in stabilizing the system; (ii) the presence of a physical space where the second messengers move by Brownian motion contributes to stabilization of the photoresponse; and (iii) keeping Ca(2+) at its dark level has only a minor effect on the variability of the system. The effects of diffusion, nonlinearity, and saturation synergize in reducing variability, supporting the notion that the observed high fidelity of the photoresponse is the result of global system function of phototransduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.