ArticleProceedings of the National Academy of Sciences of the United States of America2011
Drinking a hot blood meal elicits a protective heat shock response in mosquitoes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- Differential resistance of heat shock proteins (HSP70 and HSP90) in Anopheles culicifacies mosquitoes with respect to variations in temperature in India.Molecular biology reports · 2026Article
- The evolution of reproduction without blood feeding in an invasive vector mosquito Aedes albopictus.BMC biology · 2026Article
- Acute sublethal heat stress impairs blood feeding and trypanosome infection in the kissing bug, Rhodnius prolixus.Journal of medical entomology · 2026Article
- An Nrf2-Nup214 positive feedback loop sustains the antioxidant response and promotes microbial infection in ticks.bioRxiv : the preprint server for biology · 2026Article
- Food Deprivation inPathogens (Basel, Switzerland) · 2026Article
- Article
- Fluctuating Warm and Humid Conditions Differentially Impact Immunity and Development in the Malaria Vector Anopheles stephensi.Global change biology · 2025Article
- From Macro to Micro: De Novo Genomes of Aedes Mosquitoes Enable Comparative Genomics Among Close and Distant Relatives.Genome biology and evolution · 2025Article
- Thermal tolerance of Aedes aegypti mosquito eggs is associated with urban adaptation and human interactions.Journal of thermal biology · 2025Article
- Functional annotation and analysis of the hard tick Dermacentor nuttalli midgut genes.Parasitology research · 2025Article
- Enhanced Iteroparity Is a Correlated Response to Direct Selection on Blood Feeding in a Mosquito.Ecology and evolution · 2025Article
- The Temperature-Associated Effects of Rift Valley Fever Virus Infections in Mosquitoes and Climate-Driven Epidemics: A Review.Viruses · 2025Review
- Warmer temperature accelerates reproductive senescence in mosquitoes.Frontiers in physiology · 2025Article
- MosAIC: An annotated collection of mosquito-associated bacteria with high-quality genome assemblies.PLoS biology · 2024Article
- Temperature and time of host-seeking activity impact the efficacy of chemical control interventions targeting the West Nile virus vector, Culex tarsalis.PLoS neglected tropical diseases · 2024Article
- Phenotypic variation in biting behavior associated with differences in expression of olfactory genes in the vector mosquito, Aedes albopictus (Diptera: Culicidae).Journal of medical entomology · 2024Article
- Recognition ofBiology · 2024Article
- Heat shock proteins, thermotolerance, and insecticide resistance in mosquitoes.Frontiers in insect science · 2024Review
- Activation of immune pathways in common bed bugs,Frontiers in immunology · 2024Article
- Introducing an environmental microbiome to axenicApplied and environmental microbiology · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
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Abstract
The mosquito's body temperature increases dramatically when it takes a blood meal from a warm-blooded, vertebrate host. By using the yellow fever mosquito, Aedes aegypti, we demonstrate that this boost in temperature following a blood meal prompts the synthesis of heat shock protein 70 (Hsp70). This response, elicited by the temperature of the blood meal, is most robust in the mosquito's midgut. When RNA interference is used to suppress expression of hsp70, protein digestion of the blood meal is impaired, leading to production of fewer eggs. We propose that Hsp70 protects the mosquito midgut from the temperature stress incurred by drinking a hot blood meal. Similar increases in hsp70 were documented immediately after blood feeding in two other mosquitoes (Culex pipiens and Anopheles gambiae) and the bed bug, Cimex lectularius, suggesting that this is a common protective response in blood-feeding arthropods.
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