ArticleInfection and immunity2011
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Psychosocial stress and associations with inflammation in mid-gestation maternal, fetal, and placental tissue.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Pathogenesis of Anemia in Canine Babesiosis: Possible Contribution of Pro-Inflammatory Cytokines and Chemokines-A Review.Pathogens (Basel, Switzerland) · 2023Review
- Cell-Specific Regulation of Inflammatory Cytokines and Acute-Phase Proteins by the Glucocorticoid Receptor.Mediators of inflammation · 2023Article
- Expression of Serum Cytokines Profile in Neonatal Sepsis.Infection and drug resistance · 2022Article
- Cecal Slurry Injection in Neonatal and Adult Mice.Methods in molecular biology (Clifton, N.J.) · 2021Article
- CXCL-10: a new candidate for melanoma therapy?Cellular oncology (Dordrecht, Netherlands) · 2020Review
- BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.Science translational medicine · 2020Article
- Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation.Frontiers in immunology · 2020Article
- IL-17 inhibits CXCL9/10-mediated recruitment of CD8Journal for immunotherapy of cancer · 2019Article
- Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen.Seminars in immunopathology · 2017Review
- CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor.American journal of reproductive immunology (New York, N.Y. : 1989) · 2017Article
- S100-alarmin-induced innate immune programming protects newborn infants from sepsis.Nature immunology · 2017Article
- T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin A Exposure.Frontiers in immunology · 2017Article
- Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity.Anesthesiology · 2016Article
- Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation.Immunology · 2015Article
- Delayed emergency myelopoiesis following polymicrobial sepsis in neonates.Innate immunity · 2015Article
- The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.Disease models & mechanisms · 2015Article
- An impaired inflammatory cytokine response to gram-negative LPS in human neonates is associated with the defective TLR-mediated signaling pathway.Journal of clinical immunology · 2015Article
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Authors and funding
14 authors.
Funding
Abstract
Previous studies have suggested that neonates rely heavily on innate immunity for their antimicrobial response to bacterial infections. However, the innate immune response by neonates to bacterial infection remains poorly characterized. Here, we show that in a murine model of neonatal polymicrobial sepsis, CXC ligand 10 (CXCL10) concentrations increase in the blood and peritoneum concordant with the peritoneal recruitment of granulocytes and macrophages. Additionally, CXC receptor 3 (CXCR3) expression on elicited peritoneal macrophages and granulocytes increases following sepsis. Blockade of CXCL10 worsens not only recruitment and phagocytic function of peritoneal granulocytes and macrophages but also survival. Deletion of CXCR3 also significantly increases mortality to a septic challenge. Finally, we demonstrate that the protective adjuvant effect of pretreatment with a Toll-like receptor 4 agonist to neonatal sepsis is dependent on an endogenous CXCL10 response and that pretreatment of neonates with CXCL10 can also significantly improve macrophage and granulocyte function and modestly improve outcome to polymicrobial sepsis. Together, these data suggest a critical role for CXCL10 signaling during neonatal sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.