ArticleThe Journal of biological chemistry2011
Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer.Oncoimmunology · 2023Article
- Role of hypoxia-related proteins in adenoid cystic carcinoma invasion.Diagnostic pathology · 2020Article
- MicroRNA-29 family inhibits rhabdomyosarcoma formation and progression by regulating GEFT function.American journal of translational research · 2020Article
- Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling.Circulation · 2019Article
- NOTCH3 expression is linked to breast cancer seeding and distant metastasis.Breast cancer research : BCR · 2018Article
- Role of genetics in peripheral arterial disease outcomes; significance of limb-salvage quantitative locus-1 genes.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Article
- ADAM12 and PAPP-A: Candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts.Cell adhesion & migration · 2016Review
- Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells.Journal of Cancer · 2016Article
- Article
- Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.The American journal of pathology · 2013Article
- A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.Biochimica et biophysica acta · 2013Review
- Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype.Breast cancer research and treatment · 2013Article
- Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.The Journal of cell biology · 2013Article
- MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients.Neoplasia (New York, N.Y.) · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Metalloprotease-disintegrin ADAM12 is overexpressed and frequently mutated in breast cancer. We report here that ADAM12 expression in cultured mammalian cells is up-regulated by Notch signals. Expression of a constitutively active form of Notch1 in murine fibroblasts, myoblasts, or mammary epithelial cells or activation of the endogenous Notch signaling by co-culture with ligand-expressing cells increases ADAM12 protein and mRNA levels. Up-regulation of ADAM12 expression by Notch requires new transcription, is activated in a CSL-dependent manner, and is abolished upon inhibition of IκB kinase. Expression of a constitutively active Notch1 in NIH3T3 cells increases the stability of Adam12 mRNA. We further show that the microRNA-29 family, which has a predicted conserved site in the 3'-untranslated region of mouse Adam12, plays a critical role in mediating the stimulatory effect of Notch on ADAM12 expression. In human cells, Notch up-regulates the expression of the long form, but not the short form, of ADAM12 containing a divergent 3'-untranslated mRNA region. These studies uncover a novel paradigm in Notch signaling and establish Adam12 as a Notch-related gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.