ArticleHuman molecular genetics2011
Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.
Article in Human molecular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage inFrontiers in cell and developmental biology · 2021Article
- Design of Bivalent Nucleic Acid Ligands for Recognition of RNA-Repeated Expansion Associated with Huntington's Disease.Biochemistry · 2018Article
- Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.Acta neuropathologica · 2018Article
- GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions.Cell death & disease · 2016Article
- The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease.Frontiers in neuroscience · 2016Article
- Article
- RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis.Frontiers in cellular neuroscience · 2014Review
- Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mechanisms of RNA-induced toxicity in CAG repeat disorders.Cell death & disease · 2013Review
- Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases.Human molecular genetics · 2013Article
- RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases.Frontiers in molecular neuroscience · 2013Article
- GSK3β mediates muscle pathology in myotonic dystrophy.The Journal of clinical investigation · 2012Article
- CAG expansion induces nucleolar stress in polyglutamine diseases.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila.Human molecular genetics · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence supports a role for RNA as a common pathogenic agent in both the 'polyglutamine' and 'untranslated' dominant expanded repeat disorders. One feature of all repeat sequences currently associated with disease is their predicted ability to form a hairpin secondary structure at the RNA level. In order to investigate mechanisms by which hairpin-forming repeat RNAs could induce neurodegeneration, we have looked for alterations in gene transcript levels as hallmarks of the cellular response to toxic hairpin repeat RNAs. Three disease-associated repeat sequences--CAG, CUG and AUUCU--were specifically expressed in the neurons of Drosophila and resultant common transcriptional changes assessed by microarray analyses. Transcripts that encode several components of the Akt/Gsk3-β signalling pathway were altered as a consequence of expression of these repeat RNAs, indicating that this pathway is a component of the neuronal response to these pathogenic RNAs and may represent an important common therapeutic target in this class of diseases.
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