Evidence map›Paper›PMID 21517904›Full record

ReviewParasite immunology2011

Antimicrobial peptide killing of African trypanosomes.

J M Harrington

Abstract readReview
In one paragraph

Review in Parasite immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Plasma cytokines quantification amongMalawi medical journal : the journal of Medical Association of Malawi · 2021
    Article
  7. New Peptaibiotics and a Cyclodepsipeptide fromAntibiotics (Basel, Switzerland) · 2020
    Article
  8. Review
  9. Review
  10. Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48.International journal for parasitology. Drugs and drug resistance · 2018
    Article
  11. Killing of Trypanozoon Parasites by the Equine Cathelicidin eCATH1.Antimicrobial agents and chemotherapy · 2016
    Article
  12. Article
  13. African trypanosomiasis.Parasite immunology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

J M HarringtonDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA. jmharrin@uga.edu).
University of Georgia · US

Funding

Trypanosome Lysis by Human Haptoglobin Related ProteinR01AI039033 · NIAID · UNIVERSITY OF GEORGIA · PI HAJDUK, STEPHEN L · 1996 to 2014
$3.5M
Lysis of Trypanosomes by Haptoglobin Related ProteinR21AI039033 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HAJDUK, STEPHEN L · 2001 to 2001
$287k
Mechanism of membrane permeabilization by a cytolytic high density lipoproteinF32AI080114 · NIAID · UNIVERSITY OF GEORGIA · PI HARRINGTON, JOHN MATTHEW · 2009 to 2010
$102k
NIAID NIH HHS AI039033NIAID NIH HHS F32 AI080114NIAID NIH HHS R01 AI039033NIAID NIH HHS R21 AI039033
6 · The paper itself

Abstract

The diseases caused by trypanosomes are medically and economically devastating to the population of Sub-Saharan Africa. Parasites of the genus Trypanosoma infect both humans, causing African sleeping sickness, and livestock, causing Nagana. The development of effective treatment strategies has suffered from severe side effects of approved drugs, resistance and major difficulties in delivering drugs. Antimicrobial peptides (AMPs) are ubiquitous components of immune defence and are being rigorously pursued as novel sources of new therapeutics for a variety of pathogens. Here, we review the role of AMPs in the innate immune response of the tsetse fly to African trypanosomes, catalogue trypanocidal AMPs from diverse organisms and highlight the susceptibility of bloodstream form African trypanosomes to killing by unconventional toxic peptides.

Indexed as

AlamethicinAnimalsAntimicrobial Cationic PeptidesCell MembraneCell Membrane PermeabilityHumansLipopeptidesPeptidesPeptides, CyclicTrypanocidal AgentsTrypanosomaTsetse FliesAlamethicinAntimicrobial Cationic Peptidesleucinostatin ALipopeptidesPeptidesPeptides, CyclicTrypanocidal Agentstsushimycin

Identifiers

PMID21517904
PMCPMC3138831
OpenAlexW1559273876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.