ArticlePhysical review letters2011
Compaction and tensile forces determine the accuracy of folding landscape parameters from single molecule pulling experiments.
Article in Physical review letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Asymmetry in histone rotation in forced unwrapping and force quench rewrapping in a nucleosome.Nucleic acids research · 2021Article
- Estimating transition path times and shapes from single-molecule photon trajectories: A simulation analysis.The Journal of chemical physics · 2021Article
- Impact of hydrodynamic interactions on protein folding rates depends on temperature.Physical review. E · 2018Article
- Communication: Coordinate-dependent diffusivity from single molecule trajectories.The Journal of chemical physics · 2017Article
- Phenomenological and microscopic theories for catch bonds.Journal of structural biology · 2017Article
- Diffusive Dynamics of Contact Formation in Disordered Polypeptides.Physical review letters · 2016Article
- Extracting intrinsic dynamic parameters of biomolecular folding from single-molecule force spectroscopy experiments.Protein science : a publication of the Protein Society · 2016Article
- Reduction of All-Atom Protein Folding Dynamics to One-Dimensional Diffusion.The journal of physical chemistry. B · 2015Article
- Reconstructing folding energy landscapes from splitting probability analysis of single-molecule trajectories.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Spectral Rate Theory for Two-State Kinetics.Physical review. X · 2014Article
- Reconstructing folding energy landscapes by single-molecule force spectroscopy.Annual review of biophysics · 2014Review
- Unraveling protein-protein interactions in clathrin assemblies via atomic force spectroscopy.Methods (San Diego, Calif.) · 2013Article
- RNA under tension: Folding Landscapes, Kinetic partitioning Mechanism, and Molecular Tensegrity.The journal of physical chemistry letters · 2012Article
- Multiple barriers in forced rupture of protein complexes.The Journal of chemical physics · 2012Article
- Mechanism of enhanced mechanical stability of a minimal RNA kissing complex elucidated by nonequilibrium molecular dynamics simulations.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The molten globule state is unusually deformable under mechanical force.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Effects of pH on proteins: predictions for ensemble and single-molecule pulling experiments.Journal of the American Chemical Society · 2012Article
- Dynamic prestress in a globular protein.PLoS computational biology · 2012Article
- Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments.Physical review letters · 2011Article
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4 authors.
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Abstract
We establish a framework for assessing whether the transition state location of a biopolymer, which can be inferred from single molecule pulling experiments, corresponds to the ensemble of structures that have equal probability of reaching either the folded or unfolded states (P(fold)=0.5). Using results for the forced unfolding of a RNA hairpin, an exactly soluble model, and an analytic theory, we show that P(fold) is solely determined by s, an experimentally measurable molecular tensegrity parameter, which is a ratio of the tensile force and a compaction force that stabilizes the folded state. Applications to folding landscapes of DNA hairpins and a leucine zipper with two barriers provide a structural interpretation of single molecule experimental data. Our theory can be used to assess whether molecular extension is a good reaction coordinate using measured free energy profiles.
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